ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Med student here. I have been on TRT since 21. Here is what I have learned about ED, libido and hormones.
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 194140" data-attributes="member: 13851"><p>You need to understand how it works let alone what would be involved for GnRH to be truly effective!</p><p></p><p>Injecting once daily is pointless.</p><p></p><p></p><p><strong><em>post#45</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/not-tolerating-test-prop.19887/page-3#post-193414[/URL]</p><p></p><p><strong>Pulsatile GnRH Therapy</strong></p><p><strong></strong></p><p><strong><em>Treatment with GnRH requires subcutaneous pulsatile application using a portable pump and a butterfly needle placed in the abdominal wall and changed every 2 days</em></strong><em><strong>. The dose ranges from 5 to 20 µg/ 120 min, or 100–400 ng/kg body weight per 120 min. Low-dose pulsatile GnRH therapy (2 µg/150 min) may not elicit a sufficient pituitary response, reflecting different degrees of central maturation [16].</strong> In most cases, the induction of spermatogenesis is evidenced by the appearance of sperm in the ejaculate. Therapy lasts on average 4 months, as shown in six of seven GnRH therapy cycles in patients with idiopathic hypogonadotropic hypogonadism or Kallman syndrome [10]. Sperm counts were below the normal range of 1.2–15.3 mill/ml.</em></p><p><em></em></p><p><em></em></p><p><em><strong>When pulsatile GnRH treatment fails, a mutation of the GnRH receptor gene can be the cause</strong></em><strong><em>. These defects have been described and are probably transmitted as an autosomal recessive trait.</em></strong><em> A variable degree of hypogonadism in an affected kindred was seen: a male showed no response to pulsatile administration of GnRH, which was effective in his two sisters, all showing clinical patterns of hypogonadotropic hypogonadism [19].</em></p><p><em></em></p><p><em></em></p><p><em><strong>Another cause for failure of pulsatile GnRH treatment was observed in a patient who formed anti-GnRH antibodies during intravenous administration.</strong> This was associated with deterioration of testosterone and gonadotropin levels [20].</em></p><p></p><p></p><p></p><p></p><h3><a href="https://www.excelmale.com/forum/threads/gonadotropin-treatment-in-male-infertility.22552/" target="_blank">Gonadotropin Treatment in Male Infertility</a></h3><p><em>Male hypogonadism is often associated with impaired fertility. In special cases, treatment with gonadotropins can induce, maintain, or augment spermatogenesis. Patients responsive to such regimens are men with secondary hypogonadism, lacking gonadotropin secretion due to pituitary disorders, or...</em></p><p></p><p></p><p><strong>Table 1: Modern modalities of gonadotropin substitution therapy in men to achieve spermatogenesis and maintain androgenicity</strong></p><p><strong>[ATTACH=full]12489[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 194140, member: 13851"] You need to understand how it works let alone what would be involved for GnRH to be truly effective! Injecting once daily is pointless. [B][I]post#45[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/not-tolerating-test-prop.19887/page-3#post-193414[/URL] [B]Pulsatile GnRH Therapy [I]Treatment with GnRH requires subcutaneous pulsatile application using a portable pump and a butterfly needle placed in the abdominal wall and changed every 2 days[/I][/B][I][B]. The dose ranges from 5 to 20 µg/ 120 min, or 100–400 ng/kg body weight per 120 min. Low-dose pulsatile GnRH therapy (2 µg/150 min) may not elicit a sufficient pituitary response, reflecting different degrees of central maturation [16].[/B] In most cases, the induction of spermatogenesis is evidenced by the appearance of sperm in the ejaculate. Therapy lasts on average 4 months, as shown in six of seven GnRH therapy cycles in patients with idiopathic hypogonadotropic hypogonadism or Kallman syndrome [10]. Sperm counts were below the normal range of 1.2–15.3 mill/ml. [B]When pulsatile GnRH treatment fails, a mutation of the GnRH receptor gene can be the cause[/B][/I][B][I]. These defects have been described and are probably transmitted as an autosomal recessive trait.[/I][/B][I] A variable degree of hypogonadism in an affected kindred was seen: a male showed no response to pulsatile administration of GnRH, which was effective in his two sisters, all showing clinical patterns of hypogonadotropic hypogonadism [19]. [B]Another cause for failure of pulsatile GnRH treatment was observed in a patient who formed anti-GnRH antibodies during intravenous administration.[/B] This was associated with deterioration of testosterone and gonadotropin levels [20].[/I] [HEADING=2][URL='https://www.excelmale.com/forum/threads/gonadotropin-treatment-in-male-infertility.22552/']Gonadotropin Treatment in Male Infertility[/URL][/HEADING] [I]Male hypogonadism is often associated with impaired fertility. In special cases, treatment with gonadotropins can induce, maintain, or augment spermatogenesis. Patients responsive to such regimens are men with secondary hypogonadism, lacking gonadotropin secretion due to pituitary disorders, or...[/I] [B]Table 1: Modern modalities of gonadotropin substitution therapy in men to achieve spermatogenesis and maintain androgenicity [ATTACH type="full" alt="Screenshot (3229).png"]12489[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Med student here. I have been on TRT since 21. Here is what I have learned about ED, libido and hormones.
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top