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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone.
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<blockquote data-quote="madman" data-source="post: 148746" data-attributes="member: 13851"><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/31096185" target="_blank">MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone. - PubMed - NCBI</a></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="font-size: 18px"><strong>Abstract</strong></span></p><p><strong><span style="color: rgb(184, 49, 47)">Evidence</span> has been <span style="color: rgb(184, 49, 47)">accumulating</span> that, <span style="color: rgb(184, 49, 47)">in men</span>, some of the <span style="color: rgb(44, 130, 201)">biological actions</span> traditionally attributed to <span style="color: rgb(44, 130, 201)">testosterone acting via the androgen receptor </span>may<span style="color: rgb(0, 0, 0)"> in fact</span> <span style="color: rgb(184, 49, 47)">be dependent on its aromatisation to estradiol (E2). </span></strong>In men, E2 circulates at concentrations exceeding those of postmenopausal women, <em><strong><span style="color: rgb(184, 49, 47)">and estrogen receptors are expressed in many male reproductive and somatic tissues.</span></strong></em> Human studies contributing evidence for the role of E2 in men comprise rare case reports of men lacking aromatase or a functional estrogen receptor alpha, short term experiments manipulating sex steroid milieu in healthy men, men with organic hypogonadism or men with prostate cancer treated with androgen deprivation therapy (ADT), and from observational studies in community dwelling men.<strong> The <span style="color: rgb(184, 49, 47)">collective evidence</span> suggests that, <span style="color: rgb(184, 49, 47)">in men, E2 is an important hormone </span>for <span style="color: rgb(26, 188, 156)">hypothalamic-pituitary-testicular axis regulation, reproductive function, growth hormone-insulin-like growth factor-1 axis regulation, bone growth and maintenance of skeletal health, body composition </span><span style="color: rgb(184, 49, 47)">and </span><span style="color: rgb(26, 188, 156)">glucose metabolism,</span><span style="color: rgb(184, 49, 47)"> and </span><span style="color: rgb(26, 188, 156)">vasomotor stability.</span></strong> <strong>In other tissues, <span style="color: rgb(184, 49, 47)">particularly brain</span>, elucidation of the <span style="color: rgb(184, 49, 47)">clinical relevance of E2 actions</span> requires <span style="color: rgb(184, 49, 47)">further research.</span></strong> <strong>From a clinical perspective, <span style="color: rgb(44, 130, 201)">the current evidence supports </span>the use of <span style="color: rgb(44, 130, 201)">testosterone as the treatment of choice in male hypogonadism,</span> rather than <span style="color: rgb(184, 49, 47)">aromatase inhibitors (</span><span style="color: rgb(0, 0, 0)">which </span><span style="color: rgb(44, 130, 201)">raise testosterone</span><span style="color: rgb(0, 0, 0)"> and </span><span style="color: rgb(184, 49, 47)">lower E2), selective androgen receptor modulators, and selective estrogen receptor modulators (</span><span style="color: rgb(0, 0, 0)">with insufficiently understood tissue-specific estrogenic effects</span><span style="color: rgb(184, 49, 47)">).</span></strong> <strong>Finally, <span style="color: rgb(184, 49, 47)">E2 treatment, </span>either as add-back to <span style="color: rgb(147, 101, 184)">conventional ADT</span> or as <span style="color: rgb(0, 0, 0)">sole mode of </span><span style="color: rgb(147, 101, 184)">ADT</span> could be a useful strategy for <span style="color: rgb(147, 101, 184)">men with prostate cancer.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 148746, member: 13851"] [URL="https://www.ncbi.nlm.nih.gov/pubmed/31096185"]MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone. - PubMed - NCBI[/URL] [SIZE=18px][B]Abstract[/B][/SIZE] [B][COLOR=rgb(184, 49, 47)]Evidence[/COLOR] has been [COLOR=rgb(184, 49, 47)]accumulating[/COLOR] that, [COLOR=rgb(184, 49, 47)]in men[/COLOR], some of the [COLOR=rgb(44, 130, 201)]biological actions[/COLOR] traditionally attributed to [COLOR=rgb(44, 130, 201)]testosterone acting via the androgen receptor [/COLOR]may[COLOR=rgb(0, 0, 0)] in fact[/COLOR] [COLOR=rgb(184, 49, 47)]be dependent on its aromatisation to estradiol (E2). [/COLOR][/B]In men, E2 circulates at concentrations exceeding those of postmenopausal women, [I][B][COLOR=rgb(184, 49, 47)]and estrogen receptors are expressed in many male reproductive and somatic tissues.[/COLOR][/B][/I] Human studies contributing evidence for the role of E2 in men comprise rare case reports of men lacking aromatase or a functional estrogen receptor alpha, short term experiments manipulating sex steroid milieu in healthy men, men with organic hypogonadism or men with prostate cancer treated with androgen deprivation therapy (ADT), and from observational studies in community dwelling men.[B] The [COLOR=rgb(184, 49, 47)]collective evidence[/COLOR] suggests that, [COLOR=rgb(184, 49, 47)]in men, E2 is an important hormone [/COLOR]for [COLOR=rgb(26, 188, 156)]hypothalamic-pituitary-testicular axis regulation, reproductive function, growth hormone-insulin-like growth factor-1 axis regulation, bone growth and maintenance of skeletal health, body composition [/COLOR][COLOR=rgb(184, 49, 47)]and [/COLOR][COLOR=rgb(26, 188, 156)]glucose metabolism,[/COLOR][COLOR=rgb(184, 49, 47)] and [/COLOR][COLOR=rgb(26, 188, 156)]vasomotor stability.[/COLOR][/B][COLOR=rgb(184, 49, 47)] [/COLOR][B]In other tissues, [COLOR=rgb(184, 49, 47)]particularly brain[/COLOR], elucidation of the [COLOR=rgb(184, 49, 47)]clinical relevance of E2 actions[/COLOR] requires [COLOR=rgb(184, 49, 47)]further research.[/COLOR][/B][COLOR=rgb(184, 49, 47)] [/COLOR][B]From a clinical perspective, [COLOR=rgb(44, 130, 201)]the current evidence supports [/COLOR]the use of [COLOR=rgb(44, 130, 201)]testosterone as the treatment of choice in male hypogonadism,[/COLOR] rather than [COLOR=rgb(184, 49, 47)]aromatase inhibitors ([/COLOR][COLOR=rgb(0, 0, 0)]which [/COLOR][COLOR=rgb(44, 130, 201)]raise testosterone[/COLOR][COLOR=rgb(0, 0, 0)] and [/COLOR][COLOR=rgb(184, 49, 47)]lower E2), selective androgen receptor modulators, and selective estrogen receptor modulators ([/COLOR][COLOR=rgb(0, 0, 0)]with insufficiently understood tissue-specific estrogenic effects[/COLOR][COLOR=rgb(184, 49, 47)]).[/COLOR][/B] [B]Finally, [COLOR=rgb(184, 49, 47)]E2 treatment, [/COLOR]either as add-back to [COLOR=rgb(147, 101, 184)]conventional ADT[/COLOR] or as [COLOR=rgb(0, 0, 0)]sole mode of [/COLOR][COLOR=rgb(147, 101, 184)]ADT[/COLOR] could be a useful strategy for [COLOR=rgb(147, 101, 184)]men with prostate cancer.[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone.
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