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NDT did me little good.  I would barely get free T4 to the lower end of the range and free T3 would be in excess of the upper range.  Basically, NDT has too much T3 and not enough T4 for my condition (Hashimotos).  TSH remained elevated as a result.

My best results came when we started on levothyroxine only until we got free T4 in range and then adding in liothyronine to bring free T3 in range and overcome reverse T3.  I feel best when free T4 is in the middle-to-upper part of the range and free T3 is just slightly elevated above the upper range.  That's the only way I can get TSH to <= 2.0.

Amazing what happened once we finally got me "there" - my TPO antibodies reduced in half (still slightly elevated) with no changes other than the medication (gluten free diet, etc.).

Never once thought about the half life of T3 though.  This is definitely something to consider