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Well, you seem to have a solid relationship with the Doctor you're working with to bring your protocol into line, and that is, in many ways, half the battle. But, 40 on a non-sensitive assay is of no clinical significance. I would keep a close eye on my labs, correlate it with how you are feeling, and withdraw the AI. You are running a low, low estradiol value as of the last test. You could well be surprised at how well you feel with a higher E2 value. You can always pick Anastrozole back up.