Ruxolitinib is a medication that has been shown to induce hair regrowth in patients with alopecia areata, a condition that causes patchy or complete hair loss due to an autoimmune response[1][2][3][4][5][6]. In a proof-of-concept study, 20 mg ruxolitinib twice per day for 3-6 months induced significant hair regrowth in 9 of 12 patients with moderate-to-severe alopecia areata[1]. Another study showed that five percent of patients with moderate to severe alopecia areata had significant hair regrowth after treatment with ruxolitinib[6]. Ruxolitinib is a Janus kinase (JAK) inhibitor that prevents the JAK enzymes released by inflamed cells from affecting hair follicles[4]. While larger, randomized trials are needed to confirm the safety and efficacy of ruxolitinib in people with moderate to severe alopecia areata, initial results are very encouraging[6].
Sources
[1] Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata - PMC - NCBI Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata
[2] Successful treatment of alopecia totalis with ruxolitinib in a preadolescent patient - NCBI Successful treatment of alopecia totalis with ruxolitinib in a preadolescent patient
[3] Complete Regrowth of Beard Hair with Ruxolitinib in an Alopecia Universalis Patient Complete Regrowth of Beard Hair with Ruxolitinib in an Alopecia Universalis Patient
[4] The bald truth about ruxolitinib, the new 'miracle cure' for hair loss - The Guardian The bald truth about ruxolitinib, the new ‘miracle cure’ for hair loss
[5] Ruxolitinib cream for the treatment of patients with alopecia areata: A 2-part, double-blind, randomized, vehicle-controlled phase 2 study - ScienceDirect Ruxolitinib cream for the treatment of patients with alopecia areata: A 2-part, double-blind, randomized, vehicle-controlled phase 2 study
[6] Drug Restores Hair Growth in Patients with Alopecia Areata Drug Restores Hair Growth in Patients with Alopecia Areata
By Perplexity at https://www.perplexity.ai/search/9b34200e-3745-4e61-a3c9-1038711ce4d9
