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Most cases of gyno are not related to estradiol but low T in the presence of high IGF-1 (plus genetic predisposition). Tamoxifen may be effective since it lowers IGF-1 and estradiol. But it may not work in advanced cases of gyno.

Empower Pharmacy just created a tamoxifen nipple cream. You may want to talk to your doctor about it.

Tamoxifen (Nolvadex) Nipple Cream for Gynecomastia Now Available at Empower Pharmacy

[QUOTE="Nelson Vergel, post: 131020, member: 3"] Most cases of gyno are not related to estradiol but low T in the presence of high IGF-1 (plus genetic predisposition). Tamoxifen may be effective since it lowers IGF-1 and estradiol. But it may not work in advanced cases of gyno. Empower Pharmacy just created a tamoxifen nipple cream. You may want to talk to your doctor about it. [URL="https://www.excelmale.com/forum/threads/tamoxifen-nolvadex-nipple-cream-for-gynecomastia-now-available-at-empower-pharmacy.16396/"]Tamoxifen (Nolvadex) Nipple Cream for Gynecomastia Now Available at Empower Pharmacy[/URL] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038