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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Male infertility and intratesticular T - insight into novel serum biomarkers
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<blockquote data-quote="madman" data-source="post: 217412" data-attributes="member: 13851"><p><strong>Fig. 1 <u>An overview of 17-OHP and INSL3 as it relates to ITT</u>. Diagram of the intratesticular space to review the interactions and downstream effect of the HPG axis in the context of testosterone production and spermatogenesis. Firstly, note the production of T (testosterone) via LH, mediated by the anterior pituitary in Leydig cells as they secrete T which triggers the spermatogenesis within the seminiferous tubules by Sertoli cells. Secondly, as this spermatogenesis occurs, inhibin B and estradiol are secreted as negative feedback modulators of the anterior pituitary, along with testosterone to decrease FSH and LH secretion as opposed to activin. Thirdly, realize that the interstitial fluid in which this all occurs is occupied not only by seminiferous tubules by vascular structures as well, which carry our two main biomarkers in question, 17-OHP, and INSL3. INSL3 displays both a paracrine and autocrine function on the germ cells present within the seminiferous tubules as well as the Leydig cell itself respectively, via RXFP2 receptors. Notice also how INSL3 is constitutively expressed independently of LH activation [57].</strong></p><p><strong>[ATTACH=full]19722[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 217412, member: 13851"] [B]Fig. 1 [U]An overview of 17-OHP and INSL3 as it relates to ITT[/U]. Diagram of the intratesticular space to review the interactions and downstream effect of the HPG axis in the context of testosterone production and spermatogenesis. Firstly, note the production of T (testosterone) via LH, mediated by the anterior pituitary in Leydig cells as they secrete T which triggers the spermatogenesis within the seminiferous tubules by Sertoli cells. Secondly, as this spermatogenesis occurs, inhibin B and estradiol are secreted as negative feedback modulators of the anterior pituitary, along with testosterone to decrease FSH and LH secretion as opposed to activin. Thirdly, realize that the interstitial fluid in which this all occurs is occupied not only by seminiferous tubules by vascular structures as well, which carry our two main biomarkers in question, 17-OHP, and INSL3. INSL3 displays both a paracrine and autocrine function on the germ cells present within the seminiferous tubules as well as the Leydig cell itself respectively, via RXFP2 receptors. Notice also how INSL3 is constitutively expressed independently of LH activation [57]. [ATTACH type="full"]19722[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Male infertility and intratesticular T - insight into novel serum biomarkers
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