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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Male infertility and gonadotropin treatment
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<blockquote data-quote="madman" data-source="post: 244561" data-attributes="member: 13851"><p><strong>Fig. 2. <u>Discrimination of LH- and hCG-mediated signaling stratified by the LHCGR hinge region</u>. Both hormones bind the receptor's extracellular domain but interact differently with the “U-shaped” portion of the hinge region. (A) While hCG contacts the exon 10- encoded portion, LH spatial conformation leads to the interaction of the hormone with the sTyr331 residue. (B) These ligand-receptor interactions result in LHCGR conformational changes associated with hormone-specific intracellular signaling. Exon 10 deletion results in the shift of the sTyr residue impairing the interaction with LH, whereas the contact point of the “U-shaped” structure of the hinge region with hCG is maintained. Thus, exon 10 deletion results in a truncated LHCGR unable to mediate proper LH signaling, although it retains both LH and hCG binding capability. (C) Human LH and hCG isoforms are encoded by specific genes belonging to a genetic cluster. Both human LH and hCG act through the same receptor displaying the amino acid sequence encoded by the exon 10, which is fundamental for activating hormone-specific intracellular signaling. The deletion of the LHCGR exon 10-encoded region leads to a truncated receptor capable of binding both LH and hCG, resulting in impaired LH signaling and male infertility. Reprint with permission from Oxford University Press, Copyright 2018, Casarini et al. Endocrine Reviews, volume 39:549-592.</strong></p><p><strong>[ATTACH=full]28771[/ATTACH]</strong></p><p><strong>[ATTACH=full]28772[/ATTACH]</strong></p><p><strong>[ATTACH=full]28773[/ATTACH]</strong></p><p><strong></strong></p></blockquote><p></p>
[QUOTE="madman, post: 244561, member: 13851"] [B]Fig. 2. [U]Discrimination of LH- and hCG-mediated signaling stratified by the LHCGR hinge region[/U]. Both hormones bind the receptor's extracellular domain but interact differently with the “U-shaped” portion of the hinge region. (A) While hCG contacts the exon 10- encoded portion, LH spatial conformation leads to the interaction of the hormone with the sTyr331 residue. (B) These ligand-receptor interactions result in LHCGR conformational changes associated with hormone-specific intracellular signaling. Exon 10 deletion results in the shift of the sTyr residue impairing the interaction with LH, whereas the contact point of the “U-shaped” structure of the hinge region with hCG is maintained. Thus, exon 10 deletion results in a truncated LHCGR unable to mediate proper LH signaling, although it retains both LH and hCG binding capability. (C) Human LH and hCG isoforms are encoded by specific genes belonging to a genetic cluster. Both human LH and hCG act through the same receptor displaying the amino acid sequence encoded by the exon 10, which is fundamental for activating hormone-specific intracellular signaling. The deletion of the LHCGR exon 10-encoded region leads to a truncated receptor capable of binding both LH and hCG, resulting in impaired LH signaling and male infertility. Reprint with permission from Oxford University Press, Copyright 2018, Casarini et al. Endocrine Reviews, volume 39:549-592. [ATTACH type="full"]28771[/ATTACH] [ATTACH type="full"]28772[/ATTACH] [ATTACH type="full"]28773[/ATTACH] [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Male infertility and gonadotropin treatment
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