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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Male infertility and gonadotropin treatment
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<blockquote data-quote="madman" data-source="post: 244560" data-attributes="member: 13851"><p><strong>Fig. 1. <u>Gonadotropins' action in the male gonads</u>. LH and hCG target its Leydig cell-specific receptor, activating quantitatively and qualitatively different intracellular signaling pathways. While LH directly mediates the activation of survival and proliferative events, hCG triggers preferentially steroidogenic signals. LH signals are preferentially exerted via phosphorylation of ERK1/2 and AKT after the recruitment of G protein and b-arrestins, resulting in proliferative/antiapoptotic events. hCG is more potent than LH for activating the cAMP/PKA pathway. Still, both molecules have a qualitatively similar balance of stimulatory and inhibitory steroidogenic signals to boost the synthesis of testosterone required for spermatogenesis. The arrows' width indicates the differential activity of LH (blue arrows) and hCG (pink arrows), as described above. FSH binds its receptor expressed in Sertoli cells, stimulating the production of key growth factors and activation of mitogenic signals mainly through the cAMP/PKA pathway.</strong></p><p><strong>[ATTACH=full]28769[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 244560, member: 13851"] [B]Fig. 1. [U]Gonadotropins' action in the male gonads[/U]. LH and hCG target its Leydig cell-specific receptor, activating quantitatively and qualitatively different intracellular signaling pathways. While LH directly mediates the activation of survival and proliferative events, hCG triggers preferentially steroidogenic signals. LH signals are preferentially exerted via phosphorylation of ERK1/2 and AKT after the recruitment of G protein and b-arrestins, resulting in proliferative/antiapoptotic events. hCG is more potent than LH for activating the cAMP/PKA pathway. Still, both molecules have a qualitatively similar balance of stimulatory and inhibitory steroidogenic signals to boost the synthesis of testosterone required for spermatogenesis. The arrows' width indicates the differential activity of LH (blue arrows) and hCG (pink arrows), as described above. FSH binds its receptor expressed in Sertoli cells, stimulating the production of key growth factors and activation of mitogenic signals mainly through the cAMP/PKA pathway. [ATTACH type="full"]28769[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Male infertility and gonadotropin treatment
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