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Mental Health
Major Depressive Disorder: Next-Generation Neurosteroids
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<blockquote data-quote="Nelson Vergel" data-source="post: 211401" data-attributes="member: 3"><p>"</p><p> Brinton and her colleagues found evidence that allopregnanolone also improves mitochondrial function, redressing the “bioenergetic crisis of AD. We also think it reduces the hallmark pathologies of AD—beta amyloid deposition and phosphorylation of tau.”</p><p></p><p>Neuroinflammation is another pathophysiological mechanism in AD`, and she noted that allopregnanolone “is a very effective anti-inflammatory drug.”</p><p></p><p>Given their multiple modes of action, a role for neurosteroids in other neurodegenerative disorders seems worth pursuing, she says. “Thus far, we only have preclinical evidence in a Parkinson’s model; allopregnanolone promotes regeneration of dopaminergic fibers [which are vastly depleted in Parkinson’s]. We have to pursue that more deeply. We’re focusing on common mechanisms across age-related neurodegenerative diseases; we know, for example, that there is a bioenergetic crisis in Parkinson’s, ALS (amyotrophic lateral sclerosis), and multiple sclerosis, as well as AD. There’s also evidence allopregnanolone promotes the regeneration of white matter,” the nerve fibers that connect brain regions."</p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.dana.org/article/neurosteroids-a-major-step-forward/[/URL]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 211401, member: 3"] " Brinton and her colleagues found evidence that allopregnanolone also improves mitochondrial function, redressing the “bioenergetic crisis of AD. We also think it reduces the hallmark pathologies of AD—beta amyloid deposition and phosphorylation of tau.” Neuroinflammation is another pathophysiological mechanism in AD`, and she noted that allopregnanolone “is a very effective anti-inflammatory drug.” Given their multiple modes of action, a role for neurosteroids in other neurodegenerative disorders seems worth pursuing, she says. “Thus far, we only have preclinical evidence in a Parkinson’s model; allopregnanolone promotes regeneration of dopaminergic fibers [which are vastly depleted in Parkinson’s]. We have to pursue that more deeply. We’re focusing on common mechanisms across age-related neurodegenerative diseases; we know, for example, that there is a bioenergetic crisis in Parkinson’s, ALS (amyotrophic lateral sclerosis), and multiple sclerosis, as well as AD. There’s also evidence allopregnanolone promotes the regeneration of white matter,” the nerve fibers that connect brain regions." [URL unfurl="true"]https://www.dana.org/article/neurosteroids-a-major-step-forward/[/URL] [/QUOTE]
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Mental Health
Major Depressive Disorder: Next-Generation Neurosteroids
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