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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Maintaining LH & FSH on TRT
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<blockquote data-quote="Cataceous" data-source="post: 217376" data-attributes="member: 38109"><p>As background to others: hCG is nominally replacing the LH that's suppressed under TRT. GnRH is the upstream hormone to LH, and is also suppressed under TRT. One hypothesis is that GnRH has wider importance, as evidenced by the appearance of receptors for it in a variety of locations outside of the pituitary. Gonadorelin is synthetic GnRH, and I use it in an attempt to replace the missing GnRH. For me this correlated with improved sexual function, a recovery of libido and a noticeable improvement in cognition.</p><p></p><p>I've commented that while I initially did well with hCG added to TRT, as time went by I could not achieve the right balance. The hCG would raise my estradiol by ~20 pg/mL, which may then have pushed up prolactin, leading to sexual side effects. I experimented with both anastrozole and cabergoline, but the results were lackluster at best.</p><p></p><p>For me at least, enclomiphene must be used with gonadorelin to stimulate LH production. I've made a couple attempts at reducing or eliminating it, but each time the subjective and objective results deteriorated. The worry with enclomiphene is that in some guys it may actually create an imbalance. This speculation is brought about by the inconsistent subjective results seen in guys on monotherapy. If synthetic LH were affordable and available then I wouldn't hesitate to try adding it to the gonadorelin while foregoing the enclomiphene.</p><p></p><p>I don't know the minimum frequency of gonadorelin delivery needed to provide adequate results. If GnRH does indeed do useful things beyond make LH then any daily exposure could still be better than none. I think the 5-6 doses a day I use provide benefits even though it's not close to the natural ~16. It's possible that 2-3 doses wouldn't be much different. I recently heard that it may be possible to obtain gonadorelin as a nasal spray. If so this would potentially make frequent dosing more palatable.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217376, member: 38109"] As background to others: hCG is nominally replacing the LH that's suppressed under TRT. GnRH is the upstream hormone to LH, and is also suppressed under TRT. One hypothesis is that GnRH has wider importance, as evidenced by the appearance of receptors for it in a variety of locations outside of the pituitary. Gonadorelin is synthetic GnRH, and I use it in an attempt to replace the missing GnRH. For me this correlated with improved sexual function, a recovery of libido and a noticeable improvement in cognition. I've commented that while I initially did well with hCG added to TRT, as time went by I could not achieve the right balance. The hCG would raise my estradiol by ~20 pg/mL, which may then have pushed up prolactin, leading to sexual side effects. I experimented with both anastrozole and cabergoline, but the results were lackluster at best. For me at least, enclomiphene must be used with gonadorelin to stimulate LH production. I've made a couple attempts at reducing or eliminating it, but each time the subjective and objective results deteriorated. The worry with enclomiphene is that in some guys it may actually create an imbalance. This speculation is brought about by the inconsistent subjective results seen in guys on monotherapy. If synthetic LH were affordable and available then I wouldn't hesitate to try adding it to the gonadorelin while foregoing the enclomiphene. I don't know the minimum frequency of gonadorelin delivery needed to provide adequate results. If GnRH does indeed do useful things beyond make LH then any daily exposure could still be better than none. I think the 5-6 doses a day I use provide benefits even though it's not close to the natural ~16. It's possible that 2-3 doses wouldn't be much different. I recently heard that it may be possible to obtain gonadorelin as a nasal spray. If so this would potentially make frequent dosing more palatable. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Maintaining LH & FSH on TRT
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