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Nutrition and Supplements
Low Vitamin D Increased Muscle Related Side Effects of Statins in HIV+ people
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<blockquote data-quote="Nelson Vergel" data-source="post: 72397" data-attributes="member: 3"><p><strong>CROI: <a href="http://www.natap.org/2017/CROI/croi_257.htm" target="_blank">VITAMIN D DEFICIENCY IMPAIRS THE BENEFICIAL EFFECTS OF STATIN IN TREATED HIV</a> - - (04/06/17)</strong></p><p> <strong></strong></p><p>"The correlation between low serum 25-hydroxyvitamin D concentration and statin-induced musculoskeletal pain is debated still today, but it was proved by several observational cohort studies performed in the general population.....The association of low vitamin D levels with statin-induced myalgia in general population was also confirmed by a recent meta-analysis based on an electronic search yielding 437 articles, which investigated the effect of vitamin D levels in statin-treated patients......To conclude, low vitamin D levels seem to be associated with the development of statin-induced myalgia in HIV-infected patients under cART like in the general population, but additional, enlarged, and controlled studies are needed to examine the potential role of vitamin D deficiency in the reduced statin tolerance by HIV-infected people.....Baseline characteristics were similar between patients who experienced muscle toxicity and those who tolerated statin treatment with the exception of age, 25-hydroxyvitamin D concentration, and total duration of statin therapy. <strong>Myalgia was significantly more likely to occur in older patients (mean age, 58.6 vs. 52.5 years;</strong> P = 0.041).</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 72397, member: 3"] [B]CROI: [URL="http://www.natap.org/2017/CROI/croi_257.htm"]VITAMIN D DEFICIENCY IMPAIRS THE BENEFICIAL EFFECTS OF STATIN IN TREATED HIV[/URL] - - (04/06/17) [/B] "The correlation between low serum 25-hydroxyvitamin D concentration and statin-induced musculoskeletal pain is debated still today, but it was proved by several observational cohort studies performed in the general population.....The association of low vitamin D levels with statin-induced myalgia in general population was also confirmed by a recent meta-analysis based on an electronic search yielding 437 articles, which investigated the effect of vitamin D levels in statin-treated patients......To conclude, low vitamin D levels seem to be associated with the development of statin-induced myalgia in HIV-infected patients under cART like in the general population, but additional, enlarged, and controlled studies are needed to examine the potential role of vitamin D deficiency in the reduced statin tolerance by HIV-infected people.....Baseline characteristics were similar between patients who experienced muscle toxicity and those who tolerated statin treatment with the exception of age, 25-hydroxyvitamin D concentration, and total duration of statin therapy. [B]Myalgia was significantly more likely to occur in older patients (mean age, 58.6 vs. 52.5 years;[/B] P = 0.041). [/QUOTE]
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Low Vitamin D Increased Muscle Related Side Effects of Statins in HIV+ people
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