madman
Super Moderator
Aggressiveness of Localized Prostate Cancer: the Key Value of Testosterone Deficiency Evaluated by Both Total and Bioavailable Testosterone: AndroCan Study Results
In conclusion, we found that testosterone deficiency (defined by TT and/or BT levels) was independently associated with higher PCa aggressiveness. Furthermore, BT is a key hormonal marker, and accurate assessment of BT levels is necessary when evaluating hypogonadism in patients with localized PCa. A previously undescribed dichotomy was observed, TT having a stronger link with adiposity and BT a stronger link to cancer aggressiveness. SHBG levels should also be considered in treatment decisions.
In conclusion, we found that testosterone deficiency (defined by TT and/or BT levels) was independently associated with higher PCa aggressiveness. Furthermore, BT is a key hormonal marker, and accurate assessment of BT levels is necessary when evaluating hypogonadism in patients with localized PCa. A previously undescribed dichotomy was observed, TT having a stronger link with adiposity and BT a stronger link to cancer aggressiveness. SHBG levels should also be considered in treatment decisions.
