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Normal
No consensus has been reached regarding the lower TT threshold defining testosterone deficiency, and there are no generally accepted lower limits of normal TT. This lack of consensus follows from the fact that no studies have shown a clear threshold for TT or Free T that distinguishes men who will respond to treatment from those who will not.The number of triplet CAG repeats in androgen receptors differ in men and influences the androgen receptor activity, hence testosterone sensitivity may vary in different individuals.The same applies to androgen receptor gene CAG repeat lengths >24 in the presence of symptoms and normal testosterone levels may be considered as a state of testosterone deficiency.So don't be fooled by "within clinical levels" and think you are all good just because your TT and Free T levels are within normal ranges. The presence of symptoms might suggest you do have a testosterone deficiency.A trial of TRT on an appropriate protocol will answer your question as to whether your issues are T related.
No consensus has been reached regarding the lower TT threshold defining testosterone deficiency, and there are no generally accepted lower limits of normal TT. This lack of consensus follows from the fact that no studies have shown a clear threshold for TT or Free T that distinguishes men who will respond to treatment from those who will not.
The number of triplet CAG repeats in androgen receptors differ in men and influences the androgen receptor activity, hence testosterone sensitivity may vary in different individuals.
The same applies to androgen receptor gene CAG repeat lengths >24 in the presence of symptoms and normal testosterone levels may be considered as a state of testosterone deficiency.
So don't be fooled by "within clinical levels" and think you are all good just because your TT and Free T levels are within normal ranges. The presence of symptoms might suggest you do have a testosterone deficiency.
A trial of TRT on an appropriate protocol will answer your question as to whether your issues are T related.
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