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"We show that low total [testosterone] and [bioavailable testosterone],  but not low [estradiol] or SHBG, are associated with increased falls in  older men," the researchers wrote. "These data, using state-of-the-art  [mass spectrometry] for assessment of serum sex steroids, confirm and  extend previous findings in the U.S. MrOS cohort. Also, the effect of  [testosterone] on the likelihood of falling is mediated, at least  partly, by muscle mass and physical performance. Both falls and  bone-strength parameters are independent predictors of fracture risk in  older men. With the present data, we propose that low serum  [testosterone] influences fracture risk via an increased risk of falls  whereas low [estradiol] might increase fracture risk mainly through  reduced bone strength."

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