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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low Testosterone in Men: Recommendations on the diagnosis, treatment and monitoring
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<blockquote data-quote="tareload" data-source="post: 222701"><p><h3><span style="font-size: 15px"><span style="font-family: 'Verdana'">Note the language precision is somewhat lazy and I don't have a copy of the paper yet. My impression is most of these men were secondary and they measure the same TT with hCG monotherapy as they do with exogenous T use. Note the mention of improved symptom resolution.</span></span></h3><h3>[ATTACH=full]21497[/ATTACH]</h3><p></p><p></p><h3><a href="https://doi.org/10.1016/j.jsxm.2022.01.026" target="_blank">Safety of Human Chorionic Gonadotropin Monotherapy for Men with Previous Exogenous Testosterone Use or Replacement Therapy</a></h3><p></p><h3>Methods</h3><p></p><p>We retrospectively reviewed 50 charts <em>using exogenous T (including testosterone cypionate, clomid, anastrozole, methandienone, and testosterone gel</em>) and were switched to hCG monotherapy for at least 1 month with follow-up labs. We evaluated changes in hormones [T, LH, follicle stimulating hormone (FSH), and estradiol], hematocrit (HCT), glycated hemoglobin (A1c), and prostate specific antigen (PSA). Results presented as means standard deviation. Student t-test was used to compare pre- and post-treatment values, significance was set at p=0.05. We also evaluated for incidence of thromboembolic events, including stroke, deep vein thrombosis, and myocardial infarction.</p><p></p><p></p><h3>Results</h3><p></p><p>The average age was 43.3±10.2 years with a BMI of 29.4±3.9 kg/m2. Of the patient's reviewed, 46% had used clomid, 18% T cypionate, 15% anabolic steroids, 13% T gel, 4% T pellets, and 4% methandienone. Average follow-up after starting hCG therapy was 163 days, range 28 to 583 days. Average weekly hCG dosage was 2435 IU. Serum T experienced no significant change, from 402.54±281.34 ng/dL to 404.29 ±259.64 ng/dL (p=0.58, n=50). No change was seen in FSH (4.82±6.21 to 3.71±3.24 mIU/mL, n=25), LH (3.12±4.18 to 1.98±1.86 mIU/mL, n=25), PSA (0.79±0.39 to 0.64±0.25 ng/mL, n=6), estradiol (27.84±14.82 to 27.96±13.18 pg/mL, n=31), or A1c (5.51±0.41 to 5.41±0.0.43 %, n=8). There was a statistically significant decrease of HCT (45.05±4.87 to 43.91±4.48 %, n=15). When evaluated for improvement of erectile dysfunction (ED, n=30), low libido (n=30), and low energy (n=32), 57%, 63%, and 66% of patients reported improvement of each symptom, respectively. Only 41% of patients with ED were noted to be on another medication or therapy specifically for ED. No thromboembolic events were observed.</p><h3>Conclusions</h3><p></p><p>Weekly hCG dosing appears to have no significant effect on T levels in men with a history of exogenous T use or TRT. The majority of patients reported an improvement in their hypogonadal symptoms. No changes were noted in PSA and A1c. HCT was noted to have a small, but statistically significant decrease and no thromboembolic events were recorded.</p></blockquote><p></p>
[QUOTE="tareload, post: 222701"] [HEADING=2][SIZE=15px][FONT=Verdana]Note the language precision is somewhat lazy and I don't have a copy of the paper yet. My impression is most of these men were secondary and they measure the same TT with hCG monotherapy as they do with exogenous T use. Note the mention of improved symptom resolution.[/FONT][/SIZE][/HEADING] [HEADING=2][ATTACH type="full"]21497[/ATTACH][/HEADING] [HEADING=2][URL='https://doi.org/10.1016/j.jsxm.2022.01.026']Safety of Human Chorionic Gonadotropin Monotherapy for Men with Previous Exogenous Testosterone Use or Replacement Therapy[/URL][/HEADING] [HEADING=2]Methods[/HEADING] We retrospectively reviewed 50 charts [I]using exogenous T (including testosterone cypionate, clomid, anastrozole, methandienone, and testosterone gel[/I]) and were switched to hCG monotherapy for at least 1 month with follow-up labs. We evaluated changes in hormones [T, LH, follicle stimulating hormone (FSH), and estradiol], hematocrit (HCT), glycated hemoglobin (A1c), and prostate specific antigen (PSA). Results presented as means standard deviation. Student t-test was used to compare pre- and post-treatment values, significance was set at p=0.05. We also evaluated for incidence of thromboembolic events, including stroke, deep vein thrombosis, and myocardial infarction. [HEADING=2]Results[/HEADING] The average age was 43.3±10.2 years with a BMI of 29.4±3.9 kg/m2. Of the patient's reviewed, 46% had used clomid, 18% T cypionate, 15% anabolic steroids, 13% T gel, 4% T pellets, and 4% methandienone. Average follow-up after starting hCG therapy was 163 days, range 28 to 583 days. Average weekly hCG dosage was 2435 IU. Serum T experienced no significant change, from 402.54±281.34 ng/dL to 404.29 ±259.64 ng/dL (p=0.58, n=50). No change was seen in FSH (4.82±6.21 to 3.71±3.24 mIU/mL, n=25), LH (3.12±4.18 to 1.98±1.86 mIU/mL, n=25), PSA (0.79±0.39 to 0.64±0.25 ng/mL, n=6), estradiol (27.84±14.82 to 27.96±13.18 pg/mL, n=31), or A1c (5.51±0.41 to 5.41±0.0.43 %, n=8). There was a statistically significant decrease of HCT (45.05±4.87 to 43.91±4.48 %, n=15). When evaluated for improvement of erectile dysfunction (ED, n=30), low libido (n=30), and low energy (n=32), 57%, 63%, and 66% of patients reported improvement of each symptom, respectively. Only 41% of patients with ED were noted to be on another medication or therapy specifically for ED. No thromboembolic events were observed. [HEADING=2]Conclusions[/HEADING] Weekly hCG dosing appears to have no significant effect on T levels in men with a history of exogenous T use or TRT. The majority of patients reported an improvement in their hypogonadal symptoms. No changes were noted in PSA and A1c. HCT was noted to have a small, but statistically significant decrease and no thromboembolic events were recorded. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low Testosterone in Men: Recommendations on the diagnosis, treatment and monitoring
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