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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low Testosterone and Chronic Prostatitis/Chronic Pelvic Pain Syndrome
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<blockquote data-quote="Nelson Vergel" data-source="post: 76832" data-attributes="member: 3"><p>J Sex Med. 2016 Jul;13(7):1047-55. doi: 10.1016/j.jsxm.2016.04.070. Epub 2016 May 24.</p><p><strong>Testosterone and Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Propensity Score-Matched Analysis.</strong></p><p>Lee JH1, Lee SW2.</p><p></p><p>Abstract</p><p></p><p>INTRODUCTION:</p><p>A recent study investigated the role of testosterone (T) in chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS). However, only a small amount of data is available to date, and the results are inconsistent.</p><p></p><p>AIMS:</p><p>To evaluate the relation between total T (TT) and CP/CPPS.</p><p></p><p>METHODS:</p><p></p><p>We conducted a propensity-matched study by identifying men with a TT level lower than 3.5 ng/mL among 8,336 men in their 40s and 50s. A control group of men with a TT level of at least 3.5 ng/mL matched for age, metabolic syndrome, and body mass index at a 5:1 ratio was selected for comparison. Using the same cohort and methods, another case group (TT < 3.0 ng/mL) and control group (TT &#8805; 3.0 ng/mL) were selected. The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) was administered. A &#967;(2) test, a t-test and logistic regression analyses were used to evaluate the relation between TT and prostatitis-like symptoms.</p><p></p><p>MAIN OUTCOME MEASURES:</p><p>Association of TT with NIH-CPSI score.</p><p></p><p>RESULTS:</p><p>After propensity score matching, 948 cases (TT < 3.5 ng/mL) and 4,740 controls (TT &#8805; 3.5 ng/mL) were included. The ratio of mild and moderate to severe prostatitis-like symptoms was higher in the case group than in the control group (24.0% vs 27.4%, P = .001). The ratio of moderate to severe prostatitis-like symptoms also was higher in the case group than in the control group (6.2% vs 9.2%, P = .028). The pain domain of the NIH-CPSI, quality of life, and total NIH-CPSI scores also were higher in the case group. Ratios of severe lower urinary tract symptoms (12.6% vs 15.1%, P = .044) to maximal flow rate no higher than 10 mL/sec (3.8% vs 5.3%, P = .044) and postvoid residual urine volume of at least 100 mL (4.0% vs 5.6%, P = .035), which suggest high pressure in the prostate urethra, were higher in the case group. After adjusting for voided volume during uroflowmetry and total prostate volume, the relations of a TT level lower than 3.5 ng/mL to a maximal flow rate no higher than 10 mL/sec (odds ratio = 1.402, 95% CI = 1.017-1.934, P = .039) and to a postvoid residual urine volume of at least 100 mL (odds ratio = 1.410, 95% CI = 1.031-1.927, P = .031) were maintained. Using the cutoff TT value of 3.0 ng/mL, 437 cases (TT < 3.0 ng/mL) and 2,185 controls (TT &#8805; 3.0 ng/mL) were included. The result of the 3.0-ng/mL cutoff value for TT showed a higher incidence of prostatitis-like symptoms in the group with a TT level lower than 3.0 ng/mL, but this was not statistically significant.</p><p></p><p>CONCLUSION:</p><p>Low TT level (<3.5 ng/mL) was significantly correlated with prostatitis-like symptoms in this study.</p><p></p><p>KEYWORDS:</p><p>Chronic Pelvic Pain Syndrome; Chronic Prostatitis; Lower Urinary Tract Symptom; Prostate; Testosterone</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 76832, member: 3"] J Sex Med. 2016 Jul;13(7):1047-55. doi: 10.1016/j.jsxm.2016.04.070. Epub 2016 May 24. [B]Testosterone and Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Propensity Score-Matched Analysis.[/B] Lee JH1, Lee SW2. Abstract INTRODUCTION: A recent study investigated the role of testosterone (T) in chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS). However, only a small amount of data is available to date, and the results are inconsistent. AIMS: To evaluate the relation between total T (TT) and CP/CPPS. METHODS: We conducted a propensity-matched study by identifying men with a TT level lower than 3.5 ng/mL among 8,336 men in their 40s and 50s. A control group of men with a TT level of at least 3.5 ng/mL matched for age, metabolic syndrome, and body mass index at a 5:1 ratio was selected for comparison. Using the same cohort and methods, another case group (TT < 3.0 ng/mL) and control group (TT ≥ 3.0 ng/mL) were selected. The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) was administered. A χ(2) test, a t-test and logistic regression analyses were used to evaluate the relation between TT and prostatitis-like symptoms. MAIN OUTCOME MEASURES: Association of TT with NIH-CPSI score. RESULTS: After propensity score matching, 948 cases (TT < 3.5 ng/mL) and 4,740 controls (TT ≥ 3.5 ng/mL) were included. The ratio of mild and moderate to severe prostatitis-like symptoms was higher in the case group than in the control group (24.0% vs 27.4%, P = .001). The ratio of moderate to severe prostatitis-like symptoms also was higher in the case group than in the control group (6.2% vs 9.2%, P = .028). The pain domain of the NIH-CPSI, quality of life, and total NIH-CPSI scores also were higher in the case group. Ratios of severe lower urinary tract symptoms (12.6% vs 15.1%, P = .044) to maximal flow rate no higher than 10 mL/sec (3.8% vs 5.3%, P = .044) and postvoid residual urine volume of at least 100 mL (4.0% vs 5.6%, P = .035), which suggest high pressure in the prostate urethra, were higher in the case group. After adjusting for voided volume during uroflowmetry and total prostate volume, the relations of a TT level lower than 3.5 ng/mL to a maximal flow rate no higher than 10 mL/sec (odds ratio = 1.402, 95% CI = 1.017-1.934, P = .039) and to a postvoid residual urine volume of at least 100 mL (odds ratio = 1.410, 95% CI = 1.031-1.927, P = .031) were maintained. Using the cutoff TT value of 3.0 ng/mL, 437 cases (TT < 3.0 ng/mL) and 2,185 controls (TT ≥ 3.0 ng/mL) were included. The result of the 3.0-ng/mL cutoff value for TT showed a higher incidence of prostatitis-like symptoms in the group with a TT level lower than 3.0 ng/mL, but this was not statistically significant. CONCLUSION: Low TT level (<3.5 ng/mL) was significantly correlated with prostatitis-like symptoms in this study. KEYWORDS: Chronic Pelvic Pain Syndrome; Chronic Prostatitis; Lower Urinary Tract Symptom; Prostate; Testosterone [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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