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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low Shgb
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<blockquote data-quote="Vestpocket" data-source="post: 123920" data-attributes="member: 4848"><p>Low levels of SHBG can exponentially increase the metabolic clearance rate of testosterone, but do not significantly affect the MCR of estradiol. This leads to a potential FE2:FT imbalance.</p><p></p><p>However, the idea that men with low SHBG are on a rollercoaster is wrong.</p><p></p><p>When we talk about daily subcutaneous injections for low SHBG, we must remember: we do not inject testosterone. We inject testosterone cypionate, an inert ester of testosterone with an eight carbon chain attached to it. The more carbons a steroid ester has the more soluble it is in oil. The more soluble in oil, the harder it will be to take it out of solution, and once injected into your body, the harder to take out of adipose tissue. Enzymes within your body remove the steroid esters from the bolus created in adipose tissue and the esterase enzyme cleaves off the carbon chain via hydrolysis, releasing free testosterone and cypionic acid. This process takes time. The half life of injected testosterone cypionate is between eight and twelve days, versus the two to four hour half life of injected testosterone.</p><p></p><p>Men with low SHBG do not absorb steroid esters or free the steroid molecule any more rapidly than men with normal SHBG. The release profile remains the same. The ester acts like SHBG would in terms of buffering the hormone and releasing it slowly over time.</p><p></p><p>The peak release from a testosterone cypionate injection occurs occurs throughout the first 3 days, so there there should not be a significant rollercoaster-like effect if one injects every three days.</p><p></p><p>If steady release is the key to treating low SHBG, then daily or twice-daily use medications such as Androgel, Axiron, Striant or Natesto should work the best.</p></blockquote><p></p>
[QUOTE="Vestpocket, post: 123920, member: 4848"] Low levels of SHBG can exponentially increase the metabolic clearance rate of testosterone, but do not significantly affect the MCR of estradiol. This leads to a potential FE2:FT imbalance. However, the idea that men with low SHBG are on a rollercoaster is wrong. When we talk about daily subcutaneous injections for low SHBG, we must remember: we do not inject testosterone. We inject testosterone cypionate, an inert ester of testosterone with an eight carbon chain attached to it. The more carbons a steroid ester has the more soluble it is in oil. The more soluble in oil, the harder it will be to take it out of solution, and once injected into your body, the harder to take out of adipose tissue. Enzymes within your body remove the steroid esters from the bolus created in adipose tissue and the esterase enzyme cleaves off the carbon chain via hydrolysis, releasing free testosterone and cypionic acid. This process takes time. The half life of injected testosterone cypionate is between eight and twelve days, versus the two to four hour half life of injected testosterone. Men with low SHBG do not absorb steroid esters or free the steroid molecule any more rapidly than men with normal SHBG. The release profile remains the same. The ester acts like SHBG would in terms of buffering the hormone and releasing it slowly over time. The peak release from a testosterone cypionate injection occurs occurs throughout the first 3 days, so there there should not be a significant rollercoaster-like effect if one injects every three days. If steady release is the key to treating low SHBG, then daily or twice-daily use medications such as Androgel, Axiron, Striant or Natesto should work the best. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low Shgb
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