ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
LOW SHBG
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 173215" data-attributes="member: 38109"><p>Some interesting speculation by "James" <a href="https://www.peaktestosterone.com/forum/index.php?topic=14375.msg128805#msg128805" target="_blank">over at PeakT</a>. TL;DR is in bold:</p><p></p><p style="margin-left: 20px"><em>The half-life of free testosterone has been reported to be as low as one minute, but more modern research shows it to be closer to 6 minutes. In eugonadal men, falling serum concentrations of free hormone are replenishable by dissociation of additional free ligand from the binding protien(s).</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>With SHBG and albumin present in sufficient quantity, the half-life of testosterone becomes 34 minutes. The dissociation of T from SHBG can take up to two hours, but is actually variable based on the serum hormone concentrations.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>For example, when isolated in vitro, as serum T increases, SHBG influence on half-life becomes biphasic. However, for E2, the influence on half-life is ascending. With both albumin and SHBG present, the average half-life of T is 34 minutes, the average half-life of E2 is 60 minutes and the average half-life of DHT is 36 minutes. </em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>One key takeaway is is that the half-life of T in the body changes with serum T concentrations, becoming first longer, but then shorter as T concentrations increase (biphasic.) The metabolic clearance rate of T changes with SHBG concentrations, and is yet another factor to consider (also biphasic: exponential becomes linear progression as SHBG increases.) The half-life of E2 changes as E2 serum concentrations change, becoming longer as E2 levels rise, but metabolic clearance is not affected significantly by SHBG. E2's ascending half-life may be a side effect of this phenomenon, versus T's biphasic response.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em><strong>I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG.</strong></em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 173215, member: 38109"] Some interesting speculation by "James" [URL='https://www.peaktestosterone.com/forum/index.php?topic=14375.msg128805#msg128805']over at PeakT[/URL]. TL;DR is in bold: [INDENT][I]The half-life of free testosterone has been reported to be as low as one minute, but more modern research shows it to be closer to 6 minutes. In eugonadal men, falling serum concentrations of free hormone are replenishable by dissociation of additional free ligand from the binding protien(s).[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]With SHBG and albumin present in sufficient quantity, the half-life of testosterone becomes 34 minutes. The dissociation of T from SHBG can take up to two hours, but is actually variable based on the serum hormone concentrations.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]For example, when isolated in vitro, as serum T increases, SHBG influence on half-life becomes biphasic. However, for E2, the influence on half-life is ascending. With both albumin and SHBG present, the average half-life of T is 34 minutes, the average half-life of E2 is 60 minutes and the average half-life of DHT is 36 minutes. [/I][/INDENT] [INDENT][/INDENT] [INDENT][I]One key takeaway is is that the half-life of T in the body changes with serum T concentrations, becoming first longer, but then shorter as T concentrations increase (biphasic.) The metabolic clearance rate of T changes with SHBG concentrations, and is yet another factor to consider (also biphasic: exponential becomes linear progression as SHBG increases.) The half-life of E2 changes as E2 serum concentrations change, becoming longer as E2 levels rise, but metabolic clearance is not affected significantly by SHBG. E2's ascending half-life may be a side effect of this phenomenon, versus T's biphasic response.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I][B]I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG.[/B][/I][/INDENT] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
LOW SHBG
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top