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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Low SHBG, scrotal T cream increased DHT, drove E2 to <2
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<blockquote data-quote="Cataceous" data-source="post: 247065" data-attributes="member: 38109"><p>Indeed, I think the situation with other hormones is the same as it likely is with testosterone: the production or dose rate directly drives the free levels, with total levels dependent on the free levels and the amounts of the binding proteins. So, yes, I expect high SHBG inflates total estradiol, which could lead to misinterpreting lab results. Ideally we should be considering free estradiol, either measured or calculated or both, and especially when SHBG is low or high.</p><p></p><p></p><p></p><p>There's probably not harmonization yet, so you must use the range of the particular test. At least some of the tests seemed to correspond pretty well to results calculated via the Multi-Ligand method. In these cases a generous normal range is something like 0.2-1.5 pg/mL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 247065, member: 38109"] Indeed, I think the situation with other hormones is the same as it likely is with testosterone: the production or dose rate directly drives the free levels, with total levels dependent on the free levels and the amounts of the binding proteins. So, yes, I expect high SHBG inflates total estradiol, which could lead to misinterpreting lab results. Ideally we should be considering free estradiol, either measured or calculated or both, and especially when SHBG is low or high. There's probably not harmonization yet, so you must use the range of the particular test. At least some of the tests seemed to correspond pretty well to results calculated via the Multi-Ligand method. In these cases a generous normal range is something like 0.2-1.5 pg/mL. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Low SHBG, scrotal T cream increased DHT, drove E2 to <2
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