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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Low SHBG, scrotal T cream increased DHT, drove E2 to <2
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<blockquote data-quote="Cataceous" data-source="post: 238016" data-attributes="member: 38109"><p>I've come to prefer using ECLIA for testing estradiol due to its better reliability. However, this shouldn't be done unless you're pretty confident you won't see much cross-reactivity. If you can measure C-reactive protein and if it is low then you can probably trust an immunoassay estradiol test.</p><p></p><p>I wouldn't automatically recommend an AI for low SHBG subjects. It's true that if estradiol is high then that implies an above-normal free level as well. But I'd also want to know about the ratio of estradiol to testosterone. A normal ratio makes elevated estradiol less problematic. Are there any symptoms that could be linked to it, such as excessive emotionalism or rising prolactin?</p><p></p><p>If low SHBG people are indeed benefitting from topical testosterone then perhaps it has to do with more reasonable dosing compared to injections. This does mean less suppression of SHBG, but there may be other factors related to the reduced hormonal buffering with low SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 238016, member: 38109"] I've come to prefer using ECLIA for testing estradiol due to its better reliability. However, this shouldn't be done unless you're pretty confident you won't see much cross-reactivity. If you can measure C-reactive protein and if it is low then you can probably trust an immunoassay estradiol test. I wouldn't automatically recommend an AI for low SHBG subjects. It's true that if estradiol is high then that implies an above-normal free level as well. But I'd also want to know about the ratio of estradiol to testosterone. A normal ratio makes elevated estradiol less problematic. Are there any symptoms that could be linked to it, such as excessive emotionalism or rising prolactin? If low SHBG people are indeed benefitting from topical testosterone then perhaps it has to do with more reasonable dosing compared to injections. This does mean less suppression of SHBG, but there may be other factors related to the reduced hormonal buffering with low SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Low SHBG, scrotal T cream increased DHT, drove E2 to <2
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