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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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<blockquote data-quote="Cataceous" data-source="post: 215176" data-attributes="member: 38109"><p>It was previously hypothesized that estradiol was a problem with low SHBG—as evidenced by this rule-of-thumb floating around that says that SHBG in nMol/L should match estradiol in pg/mL. I'd thought that idea could have a basis in relatively higher free estradiol as SHBG goes down, but that's shot down by this new thinking, and we have to look at other possible mechanisms. Regardless, if the issue is still reduced androgenic activity compared to estrogenic activity then it would be justification for AI use, because just increasing testosterone is also going to increase estradiol. I would still consider all of this to be too speculative to use for treatment decisions.</p><p></p><p>Regarding dosing frequency, here's some more speculation from "James": "I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG."</p><p></p><p>To determine the credibility of these ideas I'd like to see them fleshed out with some quantitative details and references.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 215176, member: 38109"] It was previously hypothesized that estradiol was a problem with low SHBG—as evidenced by this rule-of-thumb floating around that says that SHBG in nMol/L should match estradiol in pg/mL. I'd thought that idea could have a basis in relatively higher free estradiol as SHBG goes down, but that's shot down by this new thinking, and we have to look at other possible mechanisms. Regardless, if the issue is still reduced androgenic activity compared to estrogenic activity then it would be justification for AI use, because just increasing testosterone is also going to increase estradiol. I would still consider all of this to be too speculative to use for treatment decisions. Regarding dosing frequency, here's some more speculation from "James": "I believe the fluctuations we see in low SHBG men that require 3x-7x weekly dosing are due to rapid and highly exaggerated changes in free estradiol due to the above phenomenon as peaks and troughs radically alter free hormone binding and metabolism in the absence of proportionate quantities of SHBG." To determine the credibility of these ideas I'd like to see them fleshed out with some quantitative details and references. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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