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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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<blockquote data-quote="Cataceous" data-source="post: 214215" data-attributes="member: 38109"><p>Primarily it would mean that we can't blame low SHBG for causing imbalances in the free hormone levels.</p><p></p><p>Unfortunately there's nothing definitive. Estradiol isn't necessarily off the hook. If the speculation by "James" has merit then low SHBG could result in a reduction in androgenic activity without a corresponding reduction in estrogenic activity. This would be similar to a skewed estradiol/testosterone ratio.</p><p></p><p>It's too bad that pharmaceutical-grade SHBG isn't readily available and affordable. It would be interesting to see if exogenous dosing would resolve some of the issues with low SHBG. The half-life is pretty long, so it would only need to be administered once or twice a week, assuming IM or SC administration is effective.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214215, member: 38109"] Primarily it would mean that we can't blame low SHBG for causing imbalances in the free hormone levels. Unfortunately there's nothing definitive. Estradiol isn't necessarily off the hook. If the speculation by "James" has merit then low SHBG could result in a reduction in androgenic activity without a corresponding reduction in estrogenic activity. This would be similar to a skewed estradiol/testosterone ratio. It's too bad that pharmaceutical-grade SHBG isn't readily available and affordable. It would be interesting to see if exogenous dosing would resolve some of the issues with low SHBG. The half-life is pretty long, so it would only need to be administered once or twice a week, assuming IM or SC administration is effective. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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