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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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<blockquote data-quote="Cataceous" data-source="post: 214151" data-attributes="member: 38109"><p>It's great when someone comes along and forces us to re-examine previous assumptions. If in experimenting with a free estradiol calculator you decrease SHBG while keeping free testosterone the same then you do see an increase in free estradiol, and an even larger increase in free DHT. But I'm starting to think the correct approach is to hold free estradiol and free DHT constant. These metabolites are created from free testosterone, so why should they change if free testosterone is fixed along with the underlying clearance rate constants? As with testosterone, the creation or input rate is driving the free hormone levels, and the total levels go where necessary according to SHBG, albumin, etc.</p><p></p><p>The first thing I wanted to see is if my own data support the idea that free estradiol is proportional to free testosterone. I have a few datapoints that are uncontaminated by AI or hCG use:</p><p>[ATTACH=full]18869[/ATTACH]</p><p>This is using the Mult-Ligand model. Not a perfect fit, but still within reason.</p><p></p><p>In any case, if this idea is correct then the interesting implication is that varying SHBG does not affect free estradiol or free DHT, in addition to free testosterone.</p><p></p><p>Things get more complex with the addition of exogenous DHT or an analog. This effectively drives up free DHT. In the absence of additional aromatase inhibition, free T and free E2 would not change after equilibrium is restored. But the total hormone levels would be different. If higher free DHT reduces aromatization then there could be a decrease in free estradiol and a small change in free testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214151, member: 38109"] It's great when someone comes along and forces us to re-examine previous assumptions. If in experimenting with a free estradiol calculator you decrease SHBG while keeping free testosterone the same then you do see an increase in free estradiol, and an even larger increase in free DHT. But I'm starting to think the correct approach is to hold free estradiol and free DHT constant. These metabolites are created from free testosterone, so why should they change if free testosterone is fixed along with the underlying clearance rate constants? As with testosterone, the creation or input rate is driving the free hormone levels, and the total levels go where necessary according to SHBG, albumin, etc. The first thing I wanted to see is if my own data support the idea that free estradiol is proportional to free testosterone. I have a few datapoints that are uncontaminated by AI or hCG use: [ATTACH type="full"]18869[/ATTACH] This is using the Mult-Ligand model. Not a perfect fit, but still within reason. In any case, if this idea is correct then the interesting implication is that varying SHBG does not affect free estradiol or free DHT, in addition to free testosterone. Things get more complex with the addition of exogenous DHT or an analog. This effectively drives up free DHT. In the absence of additional aromatase inhibition, free T and free E2 would not change after equilibrium is restored. But the total hormone levels would be different. If higher free DHT reduces aromatization then there could be a decrease in free estradiol and a small change in free testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
low shbg means high free E2 ?
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