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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG = lower dosed, more frequent injections. Why?
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<blockquote data-quote="TestQuest22" data-source="post: 211797" data-attributes="member: 43019"><p>It doesn't make sense to me, but I am sure there's something I'm missing. Note, I know that there is a complex relationship here, but I'm looking at this on the surface level. </p><p></p><p>Isn't the "low SHBG = more frequent injection at a lower dose" protocol a bit counterintuitive?</p><p></p><p>For example. Let's assume two individuals have the same Total T. If one has low SHBG, that means they would generally have more free T than the individual with normal or high SHBG, right?</p><p></p><p>Therefore, wouldn't injecting every few days be better for the low SHBG person, as that means more testosterone is unbound and free or bio-available vs. if they inject less testosterone more frequently?</p><p></p><p>IOW, if you have low SHBG, why inject low amounts of testosterone, only for it all (or most of it all) to end up bound? It seems like more Test, injected EOD would be better (than lower amounts of test, ED) from a logical perspective, so that the Testosterone that is not bound by SHBG can remain bio-available and have an impact.</p><p> </p><p>At a basic level, one would think that less exogenous T injected more frequently is bound by the (low) SHBG, thereby resulting in less free T. </p><p></p><p>Help me understand that relationship and recommendation, please.</p></blockquote><p></p>
[QUOTE="TestQuest22, post: 211797, member: 43019"] It doesn't make sense to me, but I am sure there's something I'm missing. Note, I know that there is a complex relationship here, but I'm looking at this on the surface level. Isn't the "low SHBG = more frequent injection at a lower dose" protocol a bit counterintuitive? For example. Let's assume two individuals have the same Total T. If one has low SHBG, that means they would generally have more free T than the individual with normal or high SHBG, right? Therefore, wouldn't injecting every few days be better for the low SHBG person, as that means more testosterone is unbound and free or bio-available vs. if they inject less testosterone more frequently? IOW, if you have low SHBG, why inject low amounts of testosterone, only for it all (or most of it all) to end up bound? It seems like more Test, injected EOD would be better (than lower amounts of test, ED) from a logical perspective, so that the Testosterone that is not bound by SHBG can remain bio-available and have an impact. At a basic level, one would think that less exogenous T injected more frequently is bound by the (low) SHBG, thereby resulting in less free T. Help me understand that relationship and recommendation, please. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG = lower dosed, more frequent injections. Why?
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