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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG guys. Will increasing injection frequency make any difference?
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<blockquote data-quote="Cataceous" data-source="post: 164714" data-attributes="member: 38109"><p>This is somewhat of a misconception, at least with regard to TRT. With exogenous testosterone you are directly controlling your level of free testosterone, and therefore also the excretion rate. SHBG in turn determines where total testosterone ends up. SHBG does not affect the rate of absorption of testosterone esters, and therefore has minimal effect on the apparent half-life of serum testosterone.</p><p></p><p>Nonetheless, there is pretty widespread belief that those with low SHBG are better off injecting frequently and with small doses. The most plausible current explanation is that this helps to keep free estradiol in check. As SHBG goes lower the ratio of free estradiol to free testosterone increases, potentially causing problems.</p><p></p><p>Edit: The premise of free estradiol increasing relative to free testosterone at low SHBG is based on an assumption of total estradiol being driven directly by free testosterone. But it seems more likely that free estradiol follows free testosterone, making total estradiol the dependent variable. In other words, neither free estradiol nor free testosterone changes much when SHBG is reduced in isolation. It's still plausible that lower SHBG leads to reduced androgenic activity relative to estrogenic activity—without a dependence on the free hormone levels.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 164714, member: 38109"] This is somewhat of a misconception, at least with regard to TRT. With exogenous testosterone you are directly controlling your level of free testosterone, and therefore also the excretion rate. SHBG in turn determines where total testosterone ends up. SHBG does not affect the rate of absorption of testosterone esters, and therefore has minimal effect on the apparent half-life of serum testosterone. Nonetheless, there is pretty widespread belief that those with low SHBG are better off injecting frequently and with small doses. The most plausible current explanation is that this helps to keep free estradiol in check. As SHBG goes lower the ratio of free estradiol to free testosterone increases, potentially causing problems. Edit: The premise of free estradiol increasing relative to free testosterone at low SHBG is based on an assumption of total estradiol being driven directly by free testosterone. But it seems more likely that free estradiol follows free testosterone, making total estradiol the dependent variable. In other words, neither free estradiol nor free testosterone changes much when SHBG is reduced in isolation. It's still plausible that lower SHBG leads to reduced androgenic activity relative to estrogenic activity—without a dependence on the free hormone levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG guys. Will increasing injection frequency make any difference?
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