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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG guys Free T/ is TT a worthless test in general?
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<blockquote data-quote="johndoesmith" data-source="post: 63972" data-attributes="member: 13404"><p>Imo free test is important, but so is SHBG, and consequently total test. </p><p></p><p>SHBG isn't just something that binds up testosterone making it useless, it is a carrier protein, which helps move a lipid soluble hormone in the aqueous blood. SHBG is important, and so is maintaining it not too high and not too low. Both are problems, we need hormones to be at goldilocks levels. </p><p></p><p>More likely than not, there wasn't time to explain this, or I am entirely wrong on this proposition. </p><p></p><p>Another thing to keep in mind, is that low SHBG means you will eliminate your testosterone much quicker than a guy with a decent SHBG level. That is the reasoning for more frequent injections. </p><p></p><p>The free hormone hypothesis states that free testosterone does the "work" but there is also the free hormone transport hypothesis, which states that the pool of free hormone is not the entire determinant of intracellular hormone level, and that the uptake of hormone from blood can be the determinant. It also states that it isn't just free hormone that is taken into cells but that some can come from the TOTAL pool, as opposed to the free hormone pool. </p><p></p><p>This is a rather complex topic. If you're interested, there's a 40 page paper on the intricacies of this topic. It's incredibly technical.</p></blockquote><p></p>
[QUOTE="johndoesmith, post: 63972, member: 13404"] Imo free test is important, but so is SHBG, and consequently total test. SHBG isn't just something that binds up testosterone making it useless, it is a carrier protein, which helps move a lipid soluble hormone in the aqueous blood. SHBG is important, and so is maintaining it not too high and not too low. Both are problems, we need hormones to be at goldilocks levels. More likely than not, there wasn't time to explain this, or I am entirely wrong on this proposition. Another thing to keep in mind, is that low SHBG means you will eliminate your testosterone much quicker than a guy with a decent SHBG level. That is the reasoning for more frequent injections. The free hormone hypothesis states that free testosterone does the "work" but there is also the free hormone transport hypothesis, which states that the pool of free hormone is not the entire determinant of intracellular hormone level, and that the uptake of hormone from blood can be the determinant. It also states that it isn't just free hormone that is taken into cells but that some can come from the TOTAL pool, as opposed to the free hormone pool. This is a rather complex topic. If you're interested, there's a 40 page paper on the intricacies of this topic. It's incredibly technical. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG guys Free T/ is TT a worthless test in general?
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