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Testosterone Replacement, Low T, HCG, & Beyond
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Low SHBG ! Good or bad?
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<blockquote data-quote="Okian" data-source="post: 14675" data-attributes="member: 2810"><p>'' <strong>Low SHBG strongly predicts risk for Type 2 diabetes</strong><strong>By Helen Albert</strong></p><p><strong>06 August 2009</strong></p><p><strong></strong></p><p><em><em>N Engl J Med</em> 2009; Advance online publication</em></p><p><em>MedWire News</em>: </p><p></p><p>Low levels of circulating sex hormone-binding globulin (SHBG) are strongly predictive for Type 2 diabetes in women and men, report researchers in the <em>New England Journal of Medicine.</em></p><p>“Circulating SHBG levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing Type 2 diabetes is uncertain,” say Simin Liu (University of California Los Angeles, USA) and colleagues.</p><p>The investigators carried out a nested case-control study of postmenopausal women in the Women’s Health Study who were not using hormone therapy at baseline. They included 359 individuals who developed Type 2 diabetes over a 10-year follow-up period and 359 controls from the same study who did not.</p><p>A replica study of an independent cohort of men from the Physicians Health Study II was also carried out, from which 170 men who developed Type 2 diabetes over 8-years of follow-up were included as well as 170 controls who did not.</p><p>The Women’s Health Study group was divided according to baseline levels of SHBG into quartiles, which ranged from a median of 17.1 to 55.8 nmol/l from the lowest to the highest quartiles, respectively. The Physicians Health Study II of men cohort was stratified in a similar fashion.</p><p>Liu <em>et al</em> found that higher levels of SHBG were strongly associated with a lower risk for Type 2 diabetes, as well as lower body mass index (BMI), lower risk for hypertension, a better lipid profile, and more favorable levels of C-reactive protein.</p><p>Compared with the lowest quartile of SHBG, women and men in the highest quartiles of circulating SHBG had a 91% and 90% reduced risk for Type 2 diabetes, respectively.</p><p>Of note, the team found that carriers of the risk allele of the SHBG gene (<em>SHBG</em>) variant rs6259 had 10% higher SHBG levels than non carriers, whereas carriers of the minor allele of the <em>SHBG</em> variant rs6257 had 10% lower plasma levels of SHBG than non carriers.</p><p>In agreement with the other findings, the rs6259 allele was associated with a lower risk and the rs6257 allele with a higher risk for Type 2 diabetes.</p><p>“These strong and consistent findings, obtained with the use of multiple analytic approaches and subgroup analyses in two independent cohorts, support the notion that SHBG may play an important role in the development of Type 2 diabetes at both the genomic and phenotypic levels,” conclude the authors.</p><p>“SHBG could be an important target in stratification for the risk of Type 2 diabetes and early intervention.”</p><p>MedWire (<a href="http://www.medwire-news.md" target="_blank">www.medwire-news.md</a>) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009</p><p></p><p><a href="http://www.medwirenews.com/57/83834/Diabetes/Low_SHBG_strongly_predicts_risk_for_Type_2_diabetes.html" target="_blank">http://www.medwirenews.com/57/83834/Diabetes/Low_SHBG_strongly_predicts_risk_for_Type_2_diabetes.html</a></p></blockquote><p></p>
[QUOTE="Okian, post: 14675, member: 2810"] '' [B]Low SHBG strongly predicts risk for Type 2 diabetes[/B][B]By Helen Albert[/B] [B]06 August 2009 [/B] [I][I]N Engl J Med[/I] 2009; Advance online publication[/I] [I]MedWire News[/I]: Low levels of circulating sex hormone-binding globulin (SHBG) are strongly predictive for Type 2 diabetes in women and men, report researchers in the [I]New England Journal of Medicine.[/I] “Circulating SHBG levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing Type 2 diabetes is uncertain,” say Simin Liu (University of California Los Angeles, USA) and colleagues. The investigators carried out a nested case-control study of postmenopausal women in the Women’s Health Study who were not using hormone therapy at baseline. They included 359 individuals who developed Type 2 diabetes over a 10-year follow-up period and 359 controls from the same study who did not. A replica study of an independent cohort of men from the Physicians Health Study II was also carried out, from which 170 men who developed Type 2 diabetes over 8-years of follow-up were included as well as 170 controls who did not. The Women’s Health Study group was divided according to baseline levels of SHBG into quartiles, which ranged from a median of 17.1 to 55.8 nmol/l from the lowest to the highest quartiles, respectively. The Physicians Health Study II of men cohort was stratified in a similar fashion. Liu [I]et al[/I] found that higher levels of SHBG were strongly associated with a lower risk for Type 2 diabetes, as well as lower body mass index (BMI), lower risk for hypertension, a better lipid profile, and more favorable levels of C-reactive protein. Compared with the lowest quartile of SHBG, women and men in the highest quartiles of circulating SHBG had a 91% and 90% reduced risk for Type 2 diabetes, respectively. Of note, the team found that carriers of the risk allele of the SHBG gene ([I]SHBG[/I]) variant rs6259 had 10% higher SHBG levels than non carriers, whereas carriers of the minor allele of the [I]SHBG[/I] variant rs6257 had 10% lower plasma levels of SHBG than non carriers. In agreement with the other findings, the rs6259 allele was associated with a lower risk and the rs6257 allele with a higher risk for Type 2 diabetes. “These strong and consistent findings, obtained with the use of multiple analytic approaches and subgroup analyses in two independent cohorts, support the notion that SHBG may play an important role in the development of Type 2 diabetes at both the genomic and phenotypic levels,” conclude the authors. “SHBG could be an important target in stratification for the risk of Type 2 diabetes and early intervention.” MedWire ([URL="http://www.medwire-news.md"]www.medwire-news.md[/URL]) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009 [URL]http://www.medwirenews.com/57/83834/Diabetes/Low_SHBG_strongly_predicts_risk_for_Type_2_diabetes.html[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG ! Good or bad?
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