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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG ! Good or bad?
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<blockquote data-quote="Okian" data-source="post: 14094" data-attributes="member: 2810"><p>Found this article which says .. '' <em><strong>low SHBG is often a sign of many of the worst chronic diseases that we face in modern, civlized societies. </strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em><em><strong>1. <u>Obesity and Being Overweight</u>. Low SHBG is associated with obesity. [1] The reason is probably due to a loss of insulin sensitivity as we'll discuss below. </strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>2. <u>Lower Insulin Levels</u>. There is evidence that increasing insulin lowers SHBG. [2] Studies have found this both in vitor and in vivo as well, i.e. on human subjects and male ones at that. [3] Therefore, SHBG is often a flag or warning signal of insulin and blood sugar issues. In other words, SHBG does not cause insulin resistance but does indicate it.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>3. <u>Cardiovascular Disease, Diabetes, Metabolic Syndrome and Decreased Longevity</u>. Due to #1 and #2, mumerous studies have shown that low SHBG can actually indicate decreased longevity. For example, one study found:</strong></em></p><p><em><strong>"Low SHBG and IGFBP-1 were both associated with an increased prevalence of abnormal glucose tolerance and the metabolic syndrome, but only SHBG was associated with diabetes mellitus. SHBG was less influenced by body mass index than IGFBP-1. Low SHBG indicated increased cardiovascular and coronary disease mortality; the association remained after adjustment for abnormal glucose tolerance, but not after adjustment for prevalent cardiovascular disease." [1]</strong></em></p><p><em><strong></strong></em></p><p><em><strong>This is about as ugly as it gets. Low SHBG is correlated with three of the biggest killers of men: heart disease, diabetes and Metabolic Syndrome. A more recent and larger scale study verified the above results but did find that all mortality risk was due to its association with diabetes, lowered HDL and weight gain. So SHBG does not seem causative, but rather often a sign that something else is wrong. By the way, it was "ischemic heart disease" risk that was associated with lowered SHBG in this case, which basically means accelerated arteriosclerosis and decreased blood supply to the heart.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><strong><em>4. <u>Apnea</u>. I document in my link on <a href="http://www.peaktestosterone.com/Apnea_Testosterone.aspx" target="_blank">Apnea and Testosterone</a> how apnea can affect your baseline testosterone levels by 30 percent or more. Other studies have shown that SHBG significantly lowers SHBG as well. [7] So if you have low testosterone and low SHBG, this is something to consider.</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>5. <u>Obesity</u>. Because weight gain can lead to loss of insulin sensitivity, low SHBG values are correlated to extra weight. </em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>6. <u>Inflammation</u>. One study (in women) found that lowered SHBG was associated with elevated CRP (C-Reactive Protein), one of the "gold standard" markers of systemic inflammation that is linked to heart disease, dementia and autoimmune disorders. [8]</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>7. <u>Hypothyroidism</u>. One study found that low SHBG was associated with hypothyroidism and could even be reversed by correcting the underlying thyroid issue. [9]</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>8. <u>Elevated Triglycerides</u>. Several studies have found that elevated triglycerides, which are a risk factor for both heart disease and erectile dysfunction, are also tied in with low SHBG. [10] Of course, this should be no shock since elevated triglycerides usually come from eating meals with an overly high glycemic load and refined carbohydrates.</em></strong></p><p><strong><em>NOTE: HRT will lower SHBG some and steroid usage even moreso.''</em></strong></p><p><strong><em></em></strong></p><p></p><p>My SHBG is currently <strong>6.95 nmol/L </strong>(14.5-48.4) nmol/L , my endocrinologist checked my thyroid,said it`s all good , I have never been overweight,tiglycerides last time checked were <strong>0.6mmol/L (</strong>0.00-2.30mmol/L) ,haven't check the other ones : diabetes ,etc.. </p><p></p><p>What are your toughts on this one please? Any help appreciated.</p></blockquote><p></p>
[QUOTE="Okian, post: 14094, member: 2810"] Found this article which says .. '' [B][/B][I][B]low SHBG is often a sign of many of the worst chronic diseases that we face in modern, civlized societies. [/B][/I][I][B]1. [U]Obesity and Being Overweight[/U]. Low SHBG is associated with obesity. [1] The reason is probably due to a loss of insulin sensitivity as we'll discuss below. [/B][/I] [I][B]2. [U]Lower Insulin Levels[/U]. There is evidence that increasing insulin lowers SHBG. [2] Studies have found this both in vitor and in vivo as well, i.e. on human subjects and male ones at that. [3] Therefore, SHBG is often a flag or warning signal of insulin and blood sugar issues. In other words, SHBG does not cause insulin resistance but does indicate it. [/B][/I] [I][B]3. [U]Cardiovascular Disease, Diabetes, Metabolic Syndrome and Decreased Longevity[/U]. Due to #1 and #2, mumerous studies have shown that low SHBG can actually indicate decreased longevity. For example, one study found:[/B][/I] [I][B]"Low SHBG and IGFBP-1 were both associated with an increased prevalence of abnormal glucose tolerance and the metabolic syndrome, but only SHBG was associated with diabetes mellitus. SHBG was less influenced by body mass index than IGFBP-1. Low SHBG indicated increased cardiovascular and coronary disease mortality; the association remained after adjustment for abnormal glucose tolerance, but not after adjustment for prevalent cardiovascular disease." [1] This is about as ugly as it gets. Low SHBG is correlated with three of the biggest killers of men: heart disease, diabetes and Metabolic Syndrome. A more recent and larger scale study verified the above results but did find that all mortality risk was due to its association with diabetes, lowered HDL and weight gain. So SHBG does not seem causative, but rather often a sign that something else is wrong. By the way, it was "ischemic heart disease" risk that was associated with lowered SHBG in this case, which basically means accelerated arteriosclerosis and decreased blood supply to the heart. [/B][/I] [B][I]4. [U]Apnea[/U]. I document in my link on [URL="http://www.peaktestosterone.com/Apnea_Testosterone.aspx"]Apnea and Testosterone[/URL] how apnea can affect your baseline testosterone levels by 30 percent or more. Other studies have shown that SHBG significantly lowers SHBG as well. [7] So if you have low testosterone and low SHBG, this is something to consider. [/I][/B] [B][I]5. [U]Obesity[/U]. Because weight gain can lead to loss of insulin sensitivity, low SHBG values are correlated to extra weight. [/I][/B] [B][I]6. [U]Inflammation[/U]. One study (in women) found that lowered SHBG was associated with elevated CRP (C-Reactive Protein), one of the "gold standard" markers of systemic inflammation that is linked to heart disease, dementia and autoimmune disorders. [8] [/I][/B] [B][I]7. [U]Hypothyroidism[/U]. One study found that low SHBG was associated with hypothyroidism and could even be reversed by correcting the underlying thyroid issue. [9] [/I][/B] [B][I]8. [U]Elevated Triglycerides[/U]. Several studies have found that elevated triglycerides, which are a risk factor for both heart disease and erectile dysfunction, are also tied in with low SHBG. [10] Of course, this should be no shock since elevated triglycerides usually come from eating meals with an overly high glycemic load and refined carbohydrates.[/I][/B] [B][I]NOTE: HRT will lower SHBG some and steroid usage even moreso.'' [/I][/B] My SHBG is currently [B]6.95 nmol/L [/B](14.5-48.4) nmol/L , my endocrinologist checked my thyroid,said it`s all good , I have never been overweight,tiglycerides last time checked were [B]0.6mmol/L ([/B]0.00-2.30mmol/L) ,haven't check the other ones : diabetes ,etc.. What are your toughts on this one please? Any help appreciated. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG ! Good or bad?
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