ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 159372" data-attributes="member: 38109"><p>Free testosterone can be calculated from total T and SHBG (ignoring albumin). You can turn it around to say that total T can be calculated from free T and SHBG. So in a situation with fairly constant free T, which I'm claiming generally applies to TRT, then you can calculate total T. And furthermore, if only SHBG changes then this means that total T adjusts appropriately to return free T to where it was before the change.</p><p></p><p>The absorption rate and the metabolic clearance rate must match in any reasonable time frame. If the rates don't match then there's not an equilibrium; testosterone is accumulating or being depleted, and serum values are in flux. But we've required the absorption rate to be constant or slowly changing, while metabolic processes have much faster time constants, on the order of minutes to a couple hours. This means that the absorption rate effectively controls free testosterone, which along with SHBG effectively controls total testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 159372, member: 38109"] Free testosterone can be calculated from total T and SHBG (ignoring albumin). You can turn it around to say that total T can be calculated from free T and SHBG. So in a situation with fairly constant free T, which I'm claiming generally applies to TRT, then you can calculate total T. And furthermore, if only SHBG changes then this means that total T adjusts appropriately to return free T to where it was before the change. The absorption rate and the metabolic clearance rate must match in any reasonable time frame. If the rates don't match then there's not an equilibrium; testosterone is accumulating or being depleted, and serum values are in flux. But we've required the absorption rate to be constant or slowly changing, while metabolic processes have much faster time constants, on the order of minutes to a couple hours. This means that the absorption rate effectively controls free testosterone, which along with SHBG effectively controls total testosterone. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top