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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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<blockquote data-quote="Cataceous" data-source="post: 159368" data-attributes="member: 38109"><p>I'm saying that treating total testosterone as the "fluctuating" number (dependent variable) is a simpler way to view things at equilibrium under TRT. This is not worrying about the more complex behavior that happens during transitions, or about actual precursors. This simplification is possible because the metabolism/excretion of testosterone must match the slow trickle entering circulation. This should hold for anyone getting his testosterone at a fairly steady rate.</p><p></p><p>Mathematically, the simplest model is this:</p><p></p><p>A_fixed_constant = T_aborption_rate = T_metabolic_clearance_rate = k * free_T</p><p></p><p>Where k is a metabolic constant. It's also true that:</p><p></p><p>free_T = f(SHBG, total_T)</p><p></p><p>But if the metabolic constant k doesn't change then at equilibrium free_T must not change either. Thus if we're examining changes in SHBG then total testosterone must change appropriately to preserve the free_T value.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 159368, member: 38109"] I'm saying that treating total testosterone as the "fluctuating" number (dependent variable) is a simpler way to view things at equilibrium under TRT. This is not worrying about the more complex behavior that happens during transitions, or about actual precursors. This simplification is possible because the metabolism/excretion of testosterone must match the slow trickle entering circulation. This should hold for anyone getting his testosterone at a fairly steady rate. Mathematically, the simplest model is this: A_fixed_constant = T_aborption_rate = T_metabolic_clearance_rate = k * free_T Where k is a metabolic constant. It's also true that: free_T = f(SHBG, total_T) But if the metabolic constant k doesn't change then at equilibrium free_T must not change either. Thus if we're examining changes in SHBG then total testosterone must change appropriately to preserve the free_T value. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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