ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 159220" data-attributes="member: 13851"><p>Adipose tissue is not the only source of conversion/aromatization.....brain, liver, kidney, bone, lung, thymus, skin, muscle!</p><p></p><p>As we know lean individuals can be over aromatizers.</p><p></p><p></p><p></p><p></p><p><strong>SOURCES OF ESTROGENS IN THE MALE </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">In the male, the free estrogens, estrone and estradiol, enter the blood both as a result of direct secretion from the testis and </span><span style="color: rgb(26, 188, 156)">extragonadal conversion from androgenic precursors (Fig. 2).</span><span style="color: rgb(184, 49, 47)"> In the testes of men, testosterone is converted to estradiol and androstenedione to estrone, releasing estradiol </span><span style="color: rgb(0, 0, 0)">(97.2-892.0 pg/ml) </span><span style="color: rgb(184, 49, 47)">and estrone </span><span style="color: rgb(0, 0, 0)">(30.0-234.8 pg/ml)</span><span style="color: rgb(184, 49, 47)"> into spermatic venous blood.</span></strong> The conversion of androstenedione to estrone is the main source of estrone entering the body [38]. <span style="color: rgb(26, 188, 156)"><strong>Extragonadal conversion or aromatization of androgen provides the other source of estrogen </strong></span><span style="color: rgb(0, 0, 0)"><strong>(25%-50%)</strong></span><span style="color: rgb(26, 188, 156)"><strong> in the male. </strong></span>The major site of androgen secretion is the testis, although the adrenal cortex also secretes smaller amounts of C,, steroids-dehydroepiandrosterone, androstenedione, and 1 1 /?-hydroxyandrosterone [7]. <strong>In many species, aromatase activity has been detected in nonneural and neural tissues, specifically in the hypothalamus and limbic system (Fig. 2).</strong> <strong><span style="color: rgb(184, 49, 47)">In most areas of the brain, the extent of in vitro aromatization is low-in the range of 1% or less of substrate metabolized.</span> <span style="color: rgb(184, 49, 47)">However, the potency of estrogen for biological actions is very high-often 10-100-fold higher than that of the parent androgen. </span>Some actions of androgen on the brain may be carried out via conversion to estrogen at the cellular level.</strong></p><p></p><p></p><p></p><p></p><p></p><p>[ATTACH=full]8301[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">FIGURE 2. </span>Physiologic sources of estrogen in the male.</strong><span style="color: rgb(184, 49, 47)"> <strong>Gonadal androgens are converted by the enzyme complex aromatase to estrogens.</strong></span><strong> Both androgens and estrogens are released into the general circulation. </strong><span style="color: rgb(26, 188, 156)"><strong>Androgens may, in addition, be aromatized to estrogens in extragonadal tissues.</strong> </span><strong>These estrogens may have local actions prior to their release into the general circulation. The adrenals normally contribute relatively minor amounts of androgens and estrogens to the circulatory pool </strong></p></blockquote><p></p>
[QUOTE="madman, post: 159220, member: 13851"] Adipose tissue is not the only source of conversion/aromatization.....brain, liver, kidney, bone, lung, thymus, skin, muscle! As we know lean individuals can be over aromatizers. [B]SOURCES OF ESTROGENS IN THE MALE [/B] [B][COLOR=rgb(184, 49, 47)]In the male, the free estrogens, estrone and estradiol, enter the blood both as a result of direct secretion from the testis and [/COLOR][COLOR=rgb(26, 188, 156)]extragonadal conversion from androgenic precursors (Fig. 2).[/COLOR][COLOR=rgb(184, 49, 47)] In the testes of men, testosterone is converted to estradiol and androstenedione to estrone, releasing estradiol [/COLOR][COLOR=rgb(0, 0, 0)](97.2-892.0 pg/ml) [/COLOR][COLOR=rgb(184, 49, 47)]and estrone [/COLOR][COLOR=rgb(0, 0, 0)](30.0-234.8 pg/ml)[/COLOR][COLOR=rgb(184, 49, 47)] into spermatic venous blood.[/COLOR][/B] The conversion of androstenedione to estrone is the main source of estrone entering the body [38]. [COLOR=rgb(26, 188, 156)][B]Extragonadal conversion or aromatization of androgen provides the other source of estrogen [/B][/COLOR][COLOR=rgb(0, 0, 0)][B](25%-50%)[/B][/COLOR][COLOR=rgb(26, 188, 156)][B] in the male. [/B][/COLOR]The major site of androgen secretion is the testis, although the adrenal cortex also secretes smaller amounts of C,, steroids-dehydroepiandrosterone, androstenedione, and 1 1 /?-hydroxyandrosterone [7]. [B]In many species, aromatase activity has been detected in nonneural and neural tissues, specifically in the hypothalamus and limbic system (Fig. 2).[/B] [B][COLOR=rgb(184, 49, 47)]In most areas of the brain, the extent of in vitro aromatization is low-in the range of 1% or less of substrate metabolized.[/COLOR] [COLOR=rgb(184, 49, 47)]However, the potency of estrogen for biological actions is very high-often 10-100-fold higher than that of the parent androgen. [/COLOR]Some actions of androgen on the brain may be carried out via conversion to estrogen at the cellular level.[/B] [ATTACH=full]8301[/ATTACH] [B][COLOR=rgb(184, 49, 47)]FIGURE 2. [/COLOR]Physiologic sources of estrogen in the male.[/B][COLOR=rgb(184, 49, 47)] [B]Gonadal androgens are converted by the enzyme complex aromatase to estrogens.[/B][/COLOR][B] Both androgens and estrogens are released into the general circulation. [/B][COLOR=rgb(26, 188, 156)][B]Androgens may, in addition, be aromatized to estrogens in extragonadal tissues.[/B] [/COLOR][B]These estrogens may have local actions prior to their release into the general circulation. The adrenals normally contribute relatively minor amounts of androgens and estrogens to the circulatory pool [/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top