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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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<blockquote data-quote="Cataceous" data-source="post: 159157" data-attributes="member: 38109"><p>On TRT the excretion rate of testosterone is controlled by the slow absorption rate. You can't eliminate it faster than you take it in. SHBG has minimal if any effect on the apparent serum half-life of testosterone. However, lower SHBG does result in proportionally lower total testosterone for the same input (dose).</p><p></p><p>But with regard to your question, I think the general idea is right: with low SHBG, estradiol is likely one of the most significant problems, if not the most. As SHBG goes lower, the ratio of free estradiol to free testosterone goes up. As Vince says, you can confirm via testing, or you can use the <a href="https://www.excelmale.com/forum/threads/spreadsheet-for-calculating-free-t-e2.17216/" target="_blank">free estradiol calculator</a>, which has shown pretty good agreement with the rather expensive free estradiol test.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 159157, member: 38109"] On TRT the excretion rate of testosterone is controlled by the slow absorption rate. You can't eliminate it faster than you take it in. SHBG has minimal if any effect on the apparent serum half-life of testosterone. However, lower SHBG does result in proportionally lower total testosterone for the same input (dose). But with regard to your question, I think the general idea is right: with low SHBG, estradiol is likely one of the most significant problems, if not the most. As SHBG goes lower, the ratio of free estradiol to free testosterone goes up. As Vince says, you can confirm via testing, or you can use the [URL='https://www.excelmale.com/forum/threads/spreadsheet-for-calculating-free-t-e2.17216/']free estradiol calculator[/URL], which has shown pretty good agreement with the rather expensive free estradiol test. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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