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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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<blockquote data-quote="falconberg" data-source="post: 159136" data-attributes="member: 19004"><p>I've been on TRT since May 2016. I'm currently on a three-month break to reassess some things and am trying to educate myself so that I can hopefully have better results if I have to get back on (which is looking increasingly likely).</p><p></p><p>I have low SHBG (currently around 18 NMOL/L, but as low as 11 NMOL/L when I am on active TRT). I understand that low SHBG means that I am binding up less of my total testosterone, leaving more free testosterone available for use. That would seem like a good thing at first blush, but (if I understand correctly) it creates a situation where I end up with too much free testosterone, which my body essentially eliminates through the urine before it can use it, followed by a dip in testosterone once I have excreted most of the exogenous testosterone that I injected. If I am misunderstanding that, please correct me.</p><p></p><p>Here's my question: Given that SHBG binds to testosterone with higher affinity than to estrogen, I am wondering if the poor success I have had with TRT is really an estradiol issue. Could it be that the limited SHBG that I do have is all being used to bind up to all of the exogenous testosterone that I am introducing, leaving no SHBG left to buffer the estradiol (both natural and converted from exogenous testosterone) running through my system?</p><p></p><p>I hope I am explaining my question correctly, but please let me know if I can clarify. I appreciate any advice. It was posts on this forum that first alerted me to the low SHBG profile and the ways that others are addressing it (more frequent doses, etc.).</p></blockquote><p></p>
[QUOTE="falconberg, post: 159136, member: 19004"] I've been on TRT since May 2016. I'm currently on a three-month break to reassess some things and am trying to educate myself so that I can hopefully have better results if I have to get back on (which is looking increasingly likely). I have low SHBG (currently around 18 NMOL/L, but as low as 11 NMOL/L when I am on active TRT). I understand that low SHBG means that I am binding up less of my total testosterone, leaving more free testosterone available for use. That would seem like a good thing at first blush, but (if I understand correctly) it creates a situation where I end up with too much free testosterone, which my body essentially eliminates through the urine before it can use it, followed by a dip in testosterone once I have excreted most of the exogenous testosterone that I injected. If I am misunderstanding that, please correct me. Here's my question: Given that SHBG binds to testosterone with higher affinity than to estrogen, I am wondering if the poor success I have had with TRT is really an estradiol issue. Could it be that the limited SHBG that I do have is all being used to bind up to all of the exogenous testosterone that I am introducing, leaving no SHBG left to buffer the estradiol (both natural and converted from exogenous testosterone) running through my system? I hope I am explaining my question correctly, but please let me know if I can clarify. I appreciate any advice. It was posts on this forum that first alerted me to the low SHBG profile and the ways that others are addressing it (more frequent doses, etc.). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG and Estradiol
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