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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Low Iron Situation
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<blockquote data-quote="Eli1947" data-source="post: 94482" data-attributes="member: 407"><p>I developed erythrocytosis and was intersted in the mechanism of this syndrom in relation to TRT. </p><p>The medical research in that area claim that testosterone inhibit hepcidin which control the iron metabolism. </p><p>Hepcidin invove in controling absorption of iron, as such too much iron pump in. This is not all there is change in the utilization of iron in the body and increasing the activity of erythropoitin receptor which cause development of too many red blood cells. So I belive before starting supplamenting Iron it is a good idea to do blood work of free iron feritin and feritin saturation etc.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/20660052" target="_blank">J Clin Endocrinol Metab.</a> 2010 Oct;95(10):4743-7. doi: 10.1210/jc.2010-0864. Epub 2010 Jul 21.</p><p><strong>Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/24158761" target="_blank">J GerontolABiol Sci Med Sci.</a> 2014 Jun;69(6):725-35. doi: 10.1093/gerona/glt154. Epub 2013 Oct 24.</p><p><strong>Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point.<a href="https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27292585" target="_blank">Clin Endocrinol (Oxf). 2016 Nov; 85(5): 772&#8211;780.</a></strong></p><p><strong>Effect of Testosterone on Hepcidin, Ferroportin, Ferritin and Iron Binding Capacity in Patients with Hypogonadotropic Hypogonadism and Type 2 DiabetesSerum hepcidin: a novel diagnostic tool in disorders of iron metabolism</strong><strong><span style="color: black">[FONT=&quot]Serum hepcidin: a noveldiagnostic tool in disorders of iron metabolism[/FONT]</span></strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Bergamaschi%20G%5BAuthor%5D&cauthor=true&cauthor_uid=19996112" target="_blank">Gaetano Bergamaschi</a>[SUP]1[/SUP] and <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Villani%20L%5BAuthor%5D&cauthor=true&cauthor_uid=19996112" target="_blank">Laura Villani</a>[SUP]2[/SUP]</p><p> </p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560343/" target="_blank">Korean J Fam Med</a>. 2013 Jan; 34(1): 66&#8211;68.</p></blockquote><p></p>
[QUOTE="Eli1947, post: 94482, member: 407"] I developed erythrocytosis and was intersted in the mechanism of this syndrom in relation to TRT. The medical research in that area claim that testosterone inhibit hepcidin which control the iron metabolism. Hepcidin invove in controling absorption of iron, as such too much iron pump in. This is not all there is change in the utilization of iron in the body and increasing the activity of erythropoitin receptor which cause development of too many red blood cells. So I belive before starting supplamenting Iron it is a good idea to do blood work of free iron feritin and feritin saturation etc. [URL="https://www.ncbi.nlm.nih.gov/pubmed/20660052"]J Clin Endocrinol Metab.[/URL] 2010 Oct;95(10):4743-7. doi: 10.1210/jc.2010-0864. Epub 2010 Jul 21. [b]Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.[/b] [URL="https://www.ncbi.nlm.nih.gov/pubmed/24158761"]J GerontolABiol Sci Med Sci.[/URL] 2014 Jun;69(6):725-35. doi: 10.1093/gerona/glt154. Epub 2013 Oct 24. [b]Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point.[URL="https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27292585"]Clin Endocrinol (Oxf). 2016 Nov; 85(5): 772–780.[/URL][/b] [b]Effect of Testosterone on Hepcidin, Ferroportin, Ferritin and Iron Binding Capacity in Patients with Hypogonadotropic Hypogonadism and Type 2 DiabetesSerum hepcidin: a novel diagnostic tool in disorders of iron metabolism[/b][b][COLOR=black][FONT="]Serum hepcidin: a noveldiagnostic tool in disorders of iron metabolism[/FONT][/COLOR][/b][URL="https://www.ncbi.nlm.nih.gov/pubmed/?term=Bergamaschi%20G%5BAuthor%5D&cauthor=true&cauthor_uid=19996112"]Gaetano Bergamaschi[/URL][SUP]1[/SUP] and [URL="https://www.ncbi.nlm.nih.gov/pubmed/?term=Villani%20L%5BAuthor%5D&cauthor=true&cauthor_uid=19996112"]Laura Villani[/URL][SUP]2[/SUP] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560343/"]Korean J Fam Med[/URL]. 2013 Jan; 34(1): 66–68. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Low Iron Situation
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