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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Low Free T
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<blockquote data-quote="madman" data-source="post: 275106" data-attributes="member: 13851"><table class='post-table ' style='width: 100%'><tr><th ><p>Report</p></th><th ><p>Result</p></th><th ><p>Ref. Range</p></th><th ><p>Units</p></th><th></th><th ><p>Status</p></th><th ><p>Lab</p></th></tr><tr><td ><p>TESTOSTERONE</p></td><td ><p>645</p></td><td ><p>300-720</p></td><td ><p>NG/DL</p></td><td></td><td ><p>Final</p></td><td ><p>CPL</p></td></tr><tr><td ><p>SEX HORM BIND GLOBULIN</p></td><td ><p>86.2</p></td><td ><p>19.3-76.4</p></td><td ><p>NMOL/L</p></td><td ><p>HIGH</p></td><td ><p>Final</p></td><td ><p>CPL</p></td></tr><tr><td ><p>CALC FREE TESTOSTERONE</p></td><td ><p>69.4</p></td><td ><p>47.0-244.0</p></td><td ><p>PG/ML</p></td><td></td><td ><p>Final</p></td><td ><p>CPL</p></td></tr></table> </p><p>I would have asked off the hop what your protocol was (dose of T/injection frequency) let alone were labs done at the true trough (lowest point) before your next injection.</p><p></p><p>You stated that you are injecting .15 mL (15 units) 200 mg/mL strength T once weekly.</p><p></p><p>Never heard of anyone prescribing 30 mg esterified T whether splitting up the dose or in your case once weekly.</p><p></p><p>This is ridiculous!</p><p></p><p>Your doctor is out to lunch or better yet on his way home!</p><p></p><p>As I have stated numerous times on the forum although TT is important to know, FT is what truly matters as it is the active unbound fraction of T responsible for the positive effects.</p><p></p><p>More importantly, when it comes to testing FT you need to use/rely on accurate assays such as the gold-standard Equilibrium Dialysis or Ultrafiltration, especially in cases of altered SHBG to know where your FT level truly sits.</p><p></p><p>The FT level you posted was calculated using the linear law-of-mass action cFTV which is available free online.</p><p></p><p>You could have figured it out on your own if you plugged in your TT, SHBG, and Albumin.</p><p></p><p>Keep in mind as of now that cFTV tends to overestimate when compared to a standardized Equilibrium Dialysis assay (most accurate) so your FT level may very well be somewhat lower.</p><p></p><p>Seeing as blood work was done at the true trough (7 days) post-injection with a robust trough TT 645 ng/dL, Albumin 4.37 g/dL and very high SHBG 86.2 nmol/L your trough FT 6.94 ng/dL is right at the bottom end reference range.</p><p></p><p>Even though you are hitting a robust trough TT your SHBG is very high.</p><p></p><p>Again good chance your trough FT may be even somewhat lower if you had it tested using an accurate assay (ED/UF).</p><p></p><p>Even then your peak TT/FT would be far from stellar.</p><p></p><p>[ATTACH=full]41113[/ATTACH]</p><p></p><p>Hard to believe any would feel good throughout the week let alone just before your next injection.</p><p></p><p>Two options here either increase your dose and stick with once weekly or better yet increase your dose and inject twice weekly.</p><p></p><p>Injecting twice-weekly will clip the peak--->trough and blood levels will be more stable throughout the week let alone you will be able to get away with running a lower weekly dose while still achieving a healthy trough FT.</p><p></p><p>The downfall with injecting once weekly is the big difference in peak--->trough and blood levels will not be as stable throughout the week.</p><p></p><p>Although some men prefer/fare well injecting once weekly many others will struggle due to the rollercoaster effect which can have a negative impact on mood, energy, libido/erectile function, and recovery.</p><p></p><p>Another problem is many get caught up in that more T is better mentality aiming for a high/absurdly high trough which is a big mistake when injecting less frequently as peak TT, FT, and estradiol levels will be through the roof.</p><p></p><p>Huge difference between someone running a trough FT 20-30 ng/dL injecting once weekly vs daily or EOD!</p><p></p><p>Keep in mind when it comes to sides (cosmetic/blood markers) peak--->trough FT plays a big role let alone where you run steady-state.</p><p></p><p>Running too high an FT even when injecting daily can lead to issues.</p><p></p><p>Running too high a trough FT on any injection protocol can be just as bad in many ways as running too low a trough FT especially when it comes to libido/erectile function a mood.</p><p></p><p>Also, tread lightly on what BP meds you dabble with as they can easily have a negative impact on erectile function.</p></blockquote><p></p>
[QUOTE="madman, post: 275106, member: 13851"] [TABLE][TR][TH]Report[/TH] [TH]Result[/TH] [TH]Ref. Range[/TH] [TH]Units[/TH] [TH][/TH] [TH]Status[/TH] [TH]Lab[/TH][/TR] [TR][TD] TESTOSTERONE [/TD] [TD] 645 [/TD] [TD] 300-720 [/TD] [TD] NG/DL [/TD] [TD] [/TD] [TD] Final [/TD] [TD] CPL [/TD][/TR] [TR][TD] SEX HORM BIND GLOBULIN [/TD] [TD] 86.2 [/TD] [TD] 19.3-76.4 [/TD] [TD] NMOL/L [/TD] [TD] HIGH [/TD] [TD] Final [/TD] [TD] CPL [/TD][/TR] [TR][TD] CALC FREE TESTOSTERONE [/TD] [TD] 69.4 [/TD] [TD] 47.0-244.0 [/TD] [TD] PG/ML [/TD] [TD] [/TD] [TD] Final [/TD] [TD] CPL [/TD][/TR][/TABLE] I would have asked off the hop what your protocol was (dose of T/injection frequency) let alone were labs done at the true trough (lowest point) before your next injection. You stated that you are injecting .15 mL (15 units) 200 mg/mL strength T once weekly. Never heard of anyone prescribing 30 mg esterified T whether splitting up the dose or in your case once weekly. This is ridiculous! Your doctor is out to lunch or better yet on his way home! As I have stated numerous times on the forum although TT is important to know, FT is what truly matters as it is the active unbound fraction of T responsible for the positive effects. More importantly, when it comes to testing FT you need to use/rely on accurate assays such as the gold-standard Equilibrium Dialysis or Ultrafiltration, especially in cases of altered SHBG to know where your FT level truly sits. The FT level you posted was calculated using the linear law-of-mass action cFTV which is available free online. You could have figured it out on your own if you plugged in your TT, SHBG, and Albumin. Keep in mind as of now that cFTV tends to overestimate when compared to a standardized Equilibrium Dialysis assay (most accurate) so your FT level may very well be somewhat lower. Seeing as blood work was done at the true trough (7 days) post-injection with a robust trough TT 645 ng/dL, Albumin 4.37 g/dL and very high SHBG 86.2 nmol/L your trough FT 6.94 ng/dL is right at the bottom end reference range. Even though you are hitting a robust trough TT your SHBG is very high. Again good chance your trough FT may be even somewhat lower if you had it tested using an accurate assay (ED/UF). Even then your peak TT/FT would be far from stellar. [ATTACH type="full" alt="1707178545953.png"]41113[/ATTACH] Hard to believe any would feel good throughout the week let alone just before your next injection. Two options here either increase your dose and stick with once weekly or better yet increase your dose and inject twice weekly. Injecting twice-weekly will clip the peak--->trough and blood levels will be more stable throughout the week let alone you will be able to get away with running a lower weekly dose while still achieving a healthy trough FT. The downfall with injecting once weekly is the big difference in peak--->trough and blood levels will not be as stable throughout the week. Although some men prefer/fare well injecting once weekly many others will struggle due to the rollercoaster effect which can have a negative impact on mood, energy, libido/erectile function, and recovery. Another problem is many get caught up in that more T is better mentality aiming for a high/absurdly high trough which is a big mistake when injecting less frequently as peak TT, FT, and estradiol levels will be through the roof. Huge difference between someone running a trough FT 20-30 ng/dL injecting once weekly vs daily or EOD! Keep in mind when it comes to sides (cosmetic/blood markers) peak--->trough FT plays a big role let alone where you run steady-state. Running too high an FT even when injecting daily can lead to issues. Running too high a trough FT on any injection protocol can be just as bad in many ways as running too low a trough FT especially when it comes to libido/erectile function a mood. Also, tread lightly on what BP meds you dabble with as they can easily have a negative impact on erectile function. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Low Free T
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