ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Low Estradiol Increases Hot Flashes and Sweating in Men with Low Testosterone
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 76841" data-attributes="member: 3"><p>Note: VMS are episodes of <strong>profuse heat accompanied by sweating and flushing, experienced predominantly around the head, neck, chest, and upper back. </strong><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Effects of Testosterone and Estradiol Deficiency on Vasomotor Symptoms in Hypogonadal Men.</strong></p><p><strong>Randomized controlled trial</strong></p><p>Taylor AP, et al. J Clin Endocrinol Metab. 2016.</p><p></p><p>Abstract</p><p>CONTEXT: The hormonal basis of vasomotor symptoms (VMS) in hypogonadal men is incompletely understood.</p><p></p><p>OBJECTIVE: To determine the contributions of testosterone and estradiol deficiency to VMS in hypogonadal men.</p><p></p><p>DESIGN: Two randomized trials were conducted sequentially between September 2004 and April 2011. Controls were recruited separately.</p><p></p><p>SETTING: A single-site academic medical center.</p><p></p><p>PARTICIPANTS: Healthy men ages 20-50, with normal serum testosterone levels.</p><p></p><p>INTERVENTION: Cohort 1 (n = 198, 81% completion) received goserelin acetate every 4 weeks to suppress gonadal steroids and were randomized to placebo or 1.25, 2.5, 5, or 10 g of testosterone gel daily for 16 weeks. Cohort 2 (n = 202, 78% completion) received the same regimen as cohort 1 plus anastrozole to block aromatization of testosterone. Controls (n = 37, 89% completion) received placebos for goserelin acetate and testosterone.</p><p></p><p>MAIN OUTCOME MEASURES: Incidence of visits with VMS. This was a preplanned secondary analysis.</p><p></p><p>RESULTS: VMS were reported at 26% of visits in cohort 1, and 35% of visits in cohort 2 (P = .02), demonstrating an effect of estradiol deficiency. When adjacent estradiol level groups in cohort 1 were compared, the largest difference in VMS incidence was observed between the 5-9.9 and 10-14.9 pg/mL groups (38% vs 16%, P < .001). In cohort 2, the 10-g testosterone group differed significantly from placebo (16% vs 43%, P = .048) after adjustment for small differences in estradiol levels, indicating that high testosterone levels may suppress VMS.</p><p></p><p>CONCLUSIONS: Estradiol deficiency is the key mediator of VMS in hypogonadal men. At high levels, testosterone may have a suppressive effect.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 76841, member: 3"] Note: [FONT=Roboto]VMS are episodes of [/FONT][B]profuse heat accompanied by sweating and flushing, experienced predominantly around the head, neck, chest, and upper back. [/B][B] Effects of Testosterone and Estradiol Deficiency on Vasomotor Symptoms in Hypogonadal Men. Randomized controlled trial[/B] Taylor AP, et al. J Clin Endocrinol Metab. 2016. Abstract CONTEXT: The hormonal basis of vasomotor symptoms (VMS) in hypogonadal men is incompletely understood. OBJECTIVE: To determine the contributions of testosterone and estradiol deficiency to VMS in hypogonadal men. DESIGN: Two randomized trials were conducted sequentially between September 2004 and April 2011. Controls were recruited separately. SETTING: A single-site academic medical center. PARTICIPANTS: Healthy men ages 20-50, with normal serum testosterone levels. INTERVENTION: Cohort 1 (n = 198, 81% completion) received goserelin acetate every 4 weeks to suppress gonadal steroids and were randomized to placebo or 1.25, 2.5, 5, or 10 g of testosterone gel daily for 16 weeks. Cohort 2 (n = 202, 78% completion) received the same regimen as cohort 1 plus anastrozole to block aromatization of testosterone. Controls (n = 37, 89% completion) received placebos for goserelin acetate and testosterone. MAIN OUTCOME MEASURES: Incidence of visits with VMS. This was a preplanned secondary analysis. RESULTS: VMS were reported at 26% of visits in cohort 1, and 35% of visits in cohort 2 (P = .02), demonstrating an effect of estradiol deficiency. When adjacent estradiol level groups in cohort 1 were compared, the largest difference in VMS incidence was observed between the 5-9.9 and 10-14.9 pg/mL groups (38% vs 16%, P < .001). In cohort 2, the 10-g testosterone group differed significantly from placebo (16% vs 43%, P = .048) after adjustment for small differences in estradiol levels, indicating that high testosterone levels may suppress VMS. CONCLUSIONS: Estradiol deficiency is the key mediator of VMS in hypogonadal men. At high levels, testosterone may have a suppressive effect. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Low Estradiol Increases Hot Flashes and Sweating in Men with Low Testosterone
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top