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Low-Dose Naltrexone
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<blockquote data-quote="Vince" data-source="post: 44694" data-attributes="member: 843"><p>[h=2]Introduction[/b]In this review, we will discuss the concept of using <em>low-dose naltrexone</em> (LDN) as a novel anti-inflammatory treatment for chronic pain conditions that are suspected to be associated with inflammatory processes. Within a specific dosage window, opioid antagonists such as naltrexone can exert a “paradoxical” analgesic effect [<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR1" target="_blank">1</a>]. We will further present the rationale for considering LDN as a primary example of a relatively new class of therapeutic agents called <em>glial cell modulators</em>. This review is intended for clinicians who are seeking additional information about the background, theory, mechanism of action, and research use of LDN. We will be focusing this discussion on LDN as a monotherapy for chronic pain. The closely related concept of ultralow-dose naltrexone involves the use of microgram, nanogram, and picogram dosages of naltrexone co-administered with opioid analgesics [<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR2" target="_blank">2</a>]. The approach is used to both increase the efficacy of opioid analgesia therapy and reduce some adverse side effects. Ultralow-dose naltrexone has been covered extensively in previous reviews [<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR3" target="_blank">3</a>] and will not be discussed here. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/" target="_blank">The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain</a></p></blockquote><p></p>
[QUOTE="Vince, post: 44694, member: 843"] [h=2]Introduction[/b]In this review, we will discuss the concept of using [I]low-dose naltrexone[/I] (LDN) as a novel anti-inflammatory treatment for chronic pain conditions that are suspected to be associated with inflammatory processes. Within a specific dosage window, opioid antagonists such as naltrexone can exert a “paradoxical” analgesic effect [[URL='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR1']1[/URL]]. We will further present the rationale for considering LDN as a primary example of a relatively new class of therapeutic agents called [I]glial cell modulators[/I]. This review is intended for clinicians who are seeking additional information about the background, theory, mechanism of action, and research use of LDN. We will be focusing this discussion on LDN as a monotherapy for chronic pain. The closely related concept of ultralow-dose naltrexone involves the use of microgram, nanogram, and picogram dosages of naltrexone co-administered with opioid analgesics [[URL='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR2']2[/URL]]. The approach is used to both increase the efficacy of opioid analgesia therapy and reduce some adverse side effects. Ultralow-dose naltrexone has been covered extensively in previous reviews [[URL='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/#CR3']3[/URL]] and will not be discussed here. [URL="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/"]The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain[/URL] [/QUOTE]
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Low-Dose Naltrexone
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