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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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<blockquote data-quote="aneuman" data-source="post: 258704" data-attributes="member: 43264"><p><h4>[USER=40205]@UCFguy01[/USER]</h4><p>Another thing to consider in your experiment is :</p><p></p><p></p><p>This means that under the action of exogenous testosterone, the effect of SERM may be limited in its ability to block negative feedback via estrogen receptor, as there may be another feedback loop that operates on the androgen receptor as well</p><p></p><p><a href="https://pubmed.ncbi.nlm.nih.gov/2493030/" target="_blank">Testosterone administration inhibits gonadotropin secretion by an effect directly on the human pituitary</a></p><p></p><p>I think [USER=38109]@Cataceous[/USER] had previously either cited or speculated on this androgenic feedback reducing the ability of SERMs to work while on exogenous T.</p><p></p><p>Probably you'd have better results using Natesto and Enclomiphene, as per:</p><p></p><p></p><p></p><p><a href="https://www.sciencedirect.com/science/article/pii/S2050052120300767" target="_blank">The Effect of Longer-Acting vs Shorter-Acting Testosterone Therapy on Follicle Stimulating Hormone and Luteinizing Hormone</a></p><p></p><p>But that would make the treatment uncomfortable, expensive and inconvenient, as Natesto has to be used at least twice a day, and based on some particular experiences, including a friend of mine, the experience can be "disgusting" although he said the effect was noticeable.</p></blockquote><p></p>
[QUOTE="aneuman, post: 258704, member: 43264"] [HEADING=3][USER=40205]@UCFguy01[/USER][/HEADING] Another thing to consider in your experiment is : This means that under the action of exogenous testosterone, the effect of SERM may be limited in its ability to block negative feedback via estrogen receptor, as there may be another feedback loop that operates on the androgen receptor as well [URL='https://pubmed.ncbi.nlm.nih.gov/2493030/']Testosterone administration inhibits gonadotropin secretion by an effect directly on the human pituitary[/URL] I think [USER=38109]@Cataceous[/USER] had previously either cited or speculated on this androgenic feedback reducing the ability of SERMs to work while on exogenous T. Probably you'd have better results using Natesto and Enclomiphene, as per: [URL='https://www.sciencedirect.com/science/article/pii/S2050052120300767']The Effect of Longer-Acting vs Shorter-Acting Testosterone Therapy on Follicle Stimulating Hormone and Luteinizing Hormone[/URL] But that would make the treatment uncomfortable, expensive and inconvenient, as Natesto has to be used at least twice a day, and based on some particular experiences, including a friend of mine, the experience can be "disgusting" although he said the effect was noticeable. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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