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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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<blockquote data-quote="aneuman" data-source="post: 258651" data-attributes="member: 43264"><p>This hypothesis appears to make sense at first, and that's the reasoning my taking Enclomiphene Citrate for more than a year, however, just as Donald Rumsfeld said, there are unknown unknowns.</p><p></p><p>EC is a SERM that "selectively" block certain estrogen receptors. Which one, I don't know. There are ER in many organs. We know for a fact that it blocks ER in the hypothalamus and the pituitary, and thus the effect in raising LH/FSH, but we don't know what other receptors could be blocking and what there effects could be. </p><p></p><p>Also, because it raises testosterone, and the aromatization process is unimpeded, the blood work may show normal or even elevated level of estradiol, when you may be feeling symptoms of low estradiol due to the blockage caused by EC, which makes it difficult for doctors to resolve as the evidence (blood work) whose otherwise.</p><p></p><p>As an anecdote, EC raised by total T to 1183 ng/dL with normal estradiol (33 pg/mL) my I did not feel any different. Perhaps there was a slight mood increase, but nothing really the makes me go back t it or recommend it in any way.</p><p></p><p>I agree and it seems to make sense...</p><p></p><p></p><p>Again, in an ideal world, it makes perfect sense, but going to my first point. For the sake of this thought experiment, let's assume there's an area of the brain responsible for libido and arousal that has an estrogen receptor. Let's assume you go with a small TRT dosage of 7mg of testosterone a day, which will put you close to the top of what most young healthy individuals produce a day. Let's say you add 6.25 mg EC every other day. Everything should be fine and dandy.</p><p></p><p>What happens if EC blocks that magical hypothetical ER in the brain killing your libido and arousal? Doest matter if your T is at 2000 ng/mL, is going to be all for naught (assuming sexual health is a goal in your experiment)</p><p></p><p>Additionally, it seems based on information provided by knowledgeable people on this forum including MDs, that if the level of testosterone is too high, such as what happens with TRT, then the androgenic feedback is too strong and cannot be overcome by blocking the ER in the pituitary/hypothalamus and LH production is shutdown anyway.</p><p></p><p>We don't know what we don't know.</p><p></p><p>As an experiment, I don't think it would be dangerous, and that would be the only way to test your hypothesis, but without a RCT, it would be difficult to remove confounding variables and declare it a success.</p></blockquote><p></p>
[QUOTE="aneuman, post: 258651, member: 43264"] This hypothesis appears to make sense at first, and that's the reasoning my taking Enclomiphene Citrate for more than a year, however, just as Donald Rumsfeld said, there are unknown unknowns. EC is a SERM that "selectively" block certain estrogen receptors. Which one, I don't know. There are ER in many organs. We know for a fact that it blocks ER in the hypothalamus and the pituitary, and thus the effect in raising LH/FSH, but we don't know what other receptors could be blocking and what there effects could be. Also, because it raises testosterone, and the aromatization process is unimpeded, the blood work may show normal or even elevated level of estradiol, when you may be feeling symptoms of low estradiol due to the blockage caused by EC, which makes it difficult for doctors to resolve as the evidence (blood work) whose otherwise. As an anecdote, EC raised by total T to 1183 ng/dL with normal estradiol (33 pg/mL) my I did not feel any different. Perhaps there was a slight mood increase, but nothing really the makes me go back t it or recommend it in any way. I agree and it seems to make sense... Again, in an ideal world, it makes perfect sense, but going to my first point. For the sake of this thought experiment, let's assume there's an area of the brain responsible for libido and arousal that has an estrogen receptor. Let's assume you go with a small TRT dosage of 7mg of testosterone a day, which will put you close to the top of what most young healthy individuals produce a day. Let's say you add 6.25 mg EC every other day. Everything should be fine and dandy. What happens if EC blocks that magical hypothetical ER in the brain killing your libido and arousal? Doest matter if your T is at 2000 ng/mL, is going to be all for naught (assuming sexual health is a goal in your experiment) Additionally, it seems based on information provided by knowledgeable people on this forum including MDs, that if the level of testosterone is too high, such as what happens with TRT, then the androgenic feedback is too strong and cannot be overcome by blocking the ER in the pituitary/hypothalamus and LH production is shutdown anyway. We don't know what we don't know. As an experiment, I don't think it would be dangerous, and that would be the only way to test your hypothesis, but without a RCT, it would be difficult to remove confounding variables and declare it a success. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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