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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low DHT is associated with low T symptoms in men with normal T
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<blockquote data-quote="madman" data-source="post: 198612" data-attributes="member: 13851"><p><strong>Limitations</strong></p><p></p><p><em><strong>This is a real-life study of patients attending a highly specialized center for treatment of andrological conditions, but despite the great number of subjects included in the analysis, several limitations should be considered. <em>A</em>s a retrospective cross-sectional study, <u>this research project does not allow us to come to definite conclusions concerning the role of DHT in the pathogenesis of selected symptoms of male aging</u>. Furthermore, this study does not measure longitudinal trends in symptoms or in endocrine status.</strong></em></p><p></p><p><strong><em>A clinical trial aiming to assess the efficacy of exogenous DHT administration was effective [30] <u>but more studies are required to understand whether treatment with either DHT (that would lack estrogenic activity and, thus, promote loss of bone mass) or rather additional T that would be 5-alpha reduced and aromatized and, thus, contribute to higher DHT levels, as well as higher estradiol concentrations, might actually improve symptoms of hypogonadism</u>.</em></strong> <strong><em><u>It also remains unclear what causes the marked differences of serum DHT concentrations within the eugonadal range of normal T levels. It may be speculated that this is caused by genetically modified expression of the 5-alpha-reductase isoenzymes</u>. It is also possible that nutritional factors such as polyunsaturated fatty acids, zinc, and green tea as well as riboflavin influence 5-alpha-reductase activity [72, 73].</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 198612, member: 13851"] [B]Limitations[/B] [I][B]This is a real-life study of patients attending a highly specialized center for treatment of andrological conditions, but despite the great number of subjects included in the analysis, several limitations should be considered. [I]A[/I]s a retrospective cross-sectional study, [U]this research project does not allow us to come to definite conclusions concerning the role of DHT in the pathogenesis of selected symptoms of male aging[/U]. Furthermore, this study does not measure longitudinal trends in symptoms or in endocrine status.[/B][/I] [B][I]A clinical trial aiming to assess the efficacy of exogenous DHT administration was effective [30] [U]but more studies are required to understand whether treatment with either DHT (that would lack estrogenic activity and, thus, promote loss of bone mass) or rather additional T that would be 5-alpha reduced and aromatized and, thus, contribute to higher DHT levels, as well as higher estradiol concentrations, might actually improve symptoms of hypogonadism[/U].[/I][/B] [B][I][U]It also remains unclear what causes the marked differences of serum DHT concentrations within the eugonadal range of normal T levels. It may be speculated that this is caused by genetically modified expression of the 5-alpha-reductase isoenzymes[/U]. It is also possible that nutritional factors such as polyunsaturated fatty acids, zinc, and green tea as well as riboflavin influence 5-alpha-reductase activity [72, 73].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Low DHT is associated with low T symptoms in men with normal T
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