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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Loss of Testosterone Increases Melanoma Risk
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<blockquote data-quote="Jinzang" data-source="post: 175010" data-attributes="member: 12925"><p>This study of castrated mice shows that loss of testosterone decreases neutrophil activity and increases risk of melanoma. Injecting the mice with testosterone pellets removed the risk. The <a href="https://www.nature.com/articles/s41467-020-15397-4" target="_blank">full text of the article</a> is available online.</p><p></p><p>"Here, we show that in castrated male mice, neutrophil maturation and function are impaired, leading to elevated metastatic burden in two models of melanoma. Replacement of testosterone effectively normalized the tumor burden in castrated male mice. Further, the aberrant neutrophil phenotype was also observed in prostate cancer patients receiving androgen deprivation therapy, highlighting the evolutionary conservation and clinical relevance of the phenotype. Taken together, these results provide a better understanding of the role of androgen signaling in neutrophil function and the impact of this biology on immune control of malignancies."</p></blockquote><p></p>
[QUOTE="Jinzang, post: 175010, member: 12925"] This study of castrated mice shows that loss of testosterone decreases neutrophil activity and increases risk of melanoma. Injecting the mice with testosterone pellets removed the risk. The [URL='https://www.nature.com/articles/s41467-020-15397-4']full text of the article[/URL] is available online. "Here, we show that in castrated male mice, neutrophil maturation and function are impaired, leading to elevated metastatic burden in two models of melanoma. Replacement of testosterone effectively normalized the tumor burden in castrated male mice. Further, the aberrant neutrophil phenotype was also observed in prostate cancer patients receiving androgen deprivation therapy, highlighting the evolutionary conservation and clinical relevance of the phenotype. Taken together, these results provide a better understanding of the role of androgen signaling in neutrophil function and the impact of this biology on immune control of malignancies." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Loss of Testosterone Increases Melanoma Risk
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