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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking to make slight change to TRT/HCG protocol; need advice
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<blockquote data-quote="madman" data-source="post: 153655" data-attributes="member: 13851"><p>Starting to get played out.....everyone complaining about high SHBG.....get back to me when you are running 100+ nmol/L!</p><p></p><p></p><p></p><p>Straight to the point:</p><p></p><p></p><p><strong>[0387]</strong> <strong><span style="color: rgb(184, 49, 47)">Relation between Percent FT with Total Testosterone and SHBG.</span> <span style="color: rgb(251, 160, 38)">Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.</span></strong><span style="color: rgb(44, 130, 201)"> <strong>Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.</strong></span> <strong><span style="color: rgb(26, 188, 156)"><strong>In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.</strong></span> <span style="color: rgb(44, 130, 201)">Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline</span></strong> <strong><span style="color: rgb(44, 130, 201)">in contrast</span> <span style="color: rgb(26, 188, 156)">to the marked decline in percent FT calculated using Vermeulen's equation.</span></strong> </p><p></p><p></p><p></p><p></p><p>Take home points that need to be <span style="color: rgb(184, 49, 47)"><strong>HAMMERED </strong></span>in the noggins of men who seem to think their SHBG is so high that extremely high TT levels are needed in order to achieve a healthy FT!<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite9" alt=":eek:" title="Eek! :eek:" loading="lazy" data-shortname=":eek:" /></p><p></p><p><strong>* <span style="color: rgb(251, 160, 38)">Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</span></strong></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>*</strong></span><span style="color: rgb(44, 130, 201)"><strong>Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations</strong></span></p><p></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">*</span><span style="color: rgb(44, 130, 201)">Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline</span></strong> <strong><span style="color: rgb(44, 130, 201)">in contrast</span> <span style="color: rgb(26, 188, 156)">to the marked decline in percent FT calculated using Vermeulen's equation.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 153655, member: 13851"] Starting to get played out.....everyone complaining about high SHBG.....get back to me when you are running 100+ nmol/L! Straight to the point: [B][0387][/B][COLOR=rgb(184, 49, 47)] [/COLOR][B][COLOR=rgb(184, 49, 47)]Relation between Percent FT with Total Testosterone and SHBG.[/COLOR] [COLOR=rgb(251, 160, 38)]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated.[/COLOR][/B][COLOR=rgb(44, 130, 201)] [B]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.[/B][/COLOR][COLOR=rgb(26, 188, 156)][B] [/B][/COLOR][B][COLOR=rgb(26, 188, 156)][B]In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.[/B][/COLOR] [COLOR=rgb(44, 130, 201)]Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline[/COLOR][/B][COLOR=rgb(44, 130, 201)] [/COLOR][B][COLOR=rgb(44, 130, 201)]in contrast[/COLOR] [COLOR=rgb(26, 188, 156)]to the marked decline in percent FT calculated using Vermeulen's equation.[/COLOR][/B][COLOR=rgb(26, 188, 156)] [/COLOR] Take home points that need to be [COLOR=rgb(184, 49, 47)][B]HAMMERED [/B][/COLOR]in the noggins of men who seem to think their SHBG is so high that extremely high TT levels are needed in order to achieve a healthy FT!:eek: [B]* [COLOR=rgb(251, 160, 38)]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/COLOR][/B] [COLOR=rgb(0, 0, 0)][B]*[/B][/COLOR][COLOR=rgb(44, 130, 201)][B]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations[/B][/COLOR] [B][COLOR=rgb(0, 0, 0)]*[/COLOR][COLOR=rgb(44, 130, 201)]Furthermore, as SHBG concentrations increase, percent FT calculated using our new model shows only a modest decline[/COLOR][/B][COLOR=rgb(44, 130, 201)] [/COLOR][B][COLOR=rgb(44, 130, 201)]in contrast[/COLOR] [COLOR=rgb(26, 188, 156)]to the marked decline in percent FT calculated using Vermeulen's equation.[/COLOR][/B][COLOR=rgb(26, 188, 156)] [/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking to make slight change to TRT/HCG protocol; need advice
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