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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking for input: Considering protocol changes to discuss with Dr Saya, to resolve side effects
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<blockquote data-quote="HealthMan" data-source="post: 103633" data-attributes="member: 13512"><p>The higher the SHBG the more testosterone bound to SHBG you will have thus lower free testosterone. So yes. High SHBG guys need higher testosterone dosage compared to low SHGB guys to achieve similar free testosterone levels. But keep in mind that low SHBG eliminates testosterone faster so depending on frequenct injection you might end up with a lower free testosterone level compared to a high SHBG guy depending on when you get bloodwork relative to injection day.</p><p></p><p>HCT has a lot to do with testosterone levels. In theory someone can eliminate HCT issues solely by reducing testosterone dosage. However for some people that are more sensitive this dosage reduction might end up meaning too low testosterone levels and no improvement in low T symptoms.</p><p></p><p>The daily testosterone theory to control HCT didn’t work for me (it actually rose my HCT). My theory on HCT is different. It has do to on how long your body has to deal with above range (or somewhat elevated testosterone level relatively speaking - having each individual physiology in mind) testosterone levels. I have heard of many cases of men switching from weekly injections to bi-weekly injections starting to have issues with HCT. More frequent injections means more stable levels and depending on the dosage more time with elevated testosterone levels causing more constant supression of hepcidin etc then causing HCT issues. Example:</p><p></p><p>Lets think about someone injecting 120mg once a week and hypothetical FT levels (upper normal range being 25)</p><p></p><p>Day 1 FT - 40</p><p>Day 2 FT - 35</p><p>Day 3 FT - 30</p><p>Day 4 FT - 25</p><p>Day 5 FT - 20</p><p>Day 6 FT - 15</p><p>Day 7 FT - 10</p><p></p><p>And now 60mg twice a week</p><p></p><p>Day 1 FT - 35</p><p>Day 2 FT - 30</p><p>Day 3 FT - 25</p><p>Day 4 FT - 40</p><p>Day 5 FT - 35</p><p>Day 6 FT - 30</p><p>Day 7 FT - 25</p><p></p><p>So using these hypothetical numbers just to ilustrate my theory. On once a week injection protocol you are only 3 days above the upper range compared to 5 days on bi-weekly injections protocol, and just one peak vs two. Also on once a week protocol on 3 days your FT is below 20 so much less estimulation on HCT. </p><p></p><p>Most of us measure testosterone levels at trough and have FT/TT close to or above upper range. So at your lowest point your testosterone level is already over theoretical physiological levels. And at peak and on average your levels are way above physiological levels. Hence problems with HCT, estradiol, etc. </p><p>By using lower dosage you can still have great benefits (if not the same benefits) of higher dosages and much lower chances of having side effects. Not saying that everybody can control side effect and still have symptoms improvement. Some people are just very sensitive to exogenous testosterone and will end up with high estradiol, HCT issues etc that will have to be dealt with an AI, blood donation etc.</p><p>We should stop chasing number and a lot of times the less is better when it comes to TRT.</p></blockquote><p></p>
[QUOTE="HealthMan, post: 103633, member: 13512"] The higher the SHBG the more testosterone bound to SHBG you will have thus lower free testosterone. So yes. High SHBG guys need higher testosterone dosage compared to low SHGB guys to achieve similar free testosterone levels. But keep in mind that low SHBG eliminates testosterone faster so depending on frequenct injection you might end up with a lower free testosterone level compared to a high SHBG guy depending on when you get bloodwork relative to injection day. HCT has a lot to do with testosterone levels. In theory someone can eliminate HCT issues solely by reducing testosterone dosage. However for some people that are more sensitive this dosage reduction might end up meaning too low testosterone levels and no improvement in low T symptoms. The daily testosterone theory to control HCT didn’t work for me (it actually rose my HCT). My theory on HCT is different. It has do to on how long your body has to deal with above range (or somewhat elevated testosterone level relatively speaking - having each individual physiology in mind) testosterone levels. I have heard of many cases of men switching from weekly injections to bi-weekly injections starting to have issues with HCT. More frequent injections means more stable levels and depending on the dosage more time with elevated testosterone levels causing more constant supression of hepcidin etc then causing HCT issues. Example: Lets think about someone injecting 120mg once a week and hypothetical FT levels (upper normal range being 25) Day 1 FT - 40 Day 2 FT - 35 Day 3 FT - 30 Day 4 FT - 25 Day 5 FT - 20 Day 6 FT - 15 Day 7 FT - 10 And now 60mg twice a week Day 1 FT - 35 Day 2 FT - 30 Day 3 FT - 25 Day 4 FT - 40 Day 5 FT - 35 Day 6 FT - 30 Day 7 FT - 25 So using these hypothetical numbers just to ilustrate my theory. On once a week injection protocol you are only 3 days above the upper range compared to 5 days on bi-weekly injections protocol, and just one peak vs two. Also on once a week protocol on 3 days your FT is below 20 so much less estimulation on HCT. Most of us measure testosterone levels at trough and have FT/TT close to or above upper range. So at your lowest point your testosterone level is already over theoretical physiological levels. And at peak and on average your levels are way above physiological levels. Hence problems with HCT, estradiol, etc. By using lower dosage you can still have great benefits (if not the same benefits) of higher dosages and much lower chances of having side effects. Not saying that everybody can control side effect and still have symptoms improvement. Some people are just very sensitive to exogenous testosterone and will end up with high estradiol, HCT issues etc that will have to be dealt with an AI, blood donation etc. We should stop chasing number and a lot of times the less is better when it comes to TRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking for input: Considering protocol changes to discuss with Dr Saya, to resolve side effects
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