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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking for input: Considering protocol changes to discuss with Dr Saya, to resolve side effects
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<blockquote data-quote="Blackhawk" data-source="post: 103622" data-attributes="member: 16042"><p>So a concern over this stuff is I don't fully understand the concept that for higher SHBG you need higher individual doses to increase free T. Somehow this is in my head, but I don't know where it came from. Is this right or wrong and if this is true, why? and where can I find studies showing this?</p><p></p><p>Do you need less frequent larger doses to accomplish this or do frequent doses, even daily, result in adequate Free T for those of us with higher SHBG?</p><p></p><p></p><p>My own reasoning regarding High HCT and E2 leads me to believe cumulative total T dosage would matter, and reducing total weekly amount would help reduce these side effects. So shooting for a given Free T level at trough on more widely spaced doses would require higher weekly totals since you have to overcome the trough effect. So by reducing doses and increasing dosing frequency you maintain more consistent levels of both total and free T with a smaller weekly total. It seems to me that going to daily injection and reducing weekly dose could help drop HCT and E2 while keeping free T around 20.</p><p></p><p>Is this sound reasoning or what am I missing?</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 103622, member: 16042"] So a concern over this stuff is I don't fully understand the concept that for higher SHBG you need higher individual doses to increase free T. Somehow this is in my head, but I don't know where it came from. Is this right or wrong and if this is true, why? and where can I find studies showing this? Do you need less frequent larger doses to accomplish this or do frequent doses, even daily, result in adequate Free T for those of us with higher SHBG? My own reasoning regarding High HCT and E2 leads me to believe cumulative total T dosage would matter, and reducing total weekly amount would help reduce these side effects. So shooting for a given Free T level at trough on more widely spaced doses would require higher weekly totals since you have to overcome the trough effect. So by reducing doses and increasing dosing frequency you maintain more consistent levels of both total and free T with a smaller weekly total. It seems to me that going to daily injection and reducing weekly dose could help drop HCT and E2 while keeping free T around 20. Is this sound reasoning or what am I missing? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Looking for input: Considering protocol changes to discuss with Dr Saya, to resolve side effects
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