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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Long-term testosterone supplementation augments overnight growth hormone secretion
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<blockquote data-quote="Nelson Vergel" data-source="post: 7478" data-attributes="member: 3"><p>Even though this study used a low dose of testosterone (100 mg every two weeks of testosterone enanthate injections) in older men with low T, it showed that T supplementation can increase night time growth hormone output.</p><p></p><p>[ATTACH]726[/ATTACH]</p><p></p><p><strong>Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men</strong></p><p></p><p></p><p>- Endocrinology and Metabolism Published 1 September 2007 <strong>Vol.</strong> 293 <strong>no.</strong> E769-E775</p><p></p><p>Circulating testosterone (T) and GH/IGF-I are diminished in healthy aging men. Short-term administration of high doses of T augments GH secretion in older men. However, effects of long-term, low-dose T supplementation on GH secretion are unknown. </p><p></p><p>Our objective was to evaluate effects of long-term, low-dose T administration on nocturnal GH secretory dynamics and AM concentrations of IGF-I and IGFBP-3 in healthy older men (65&#8211;88 yr, <em>n</em> = 34) with low-normal T and IGF-I. </p><p></p><p>In a double-masked, placebo-controlled, randomized study we assessed effects of low-dose T supplementation (100 mg im every 2 wk) for 26 wk on nocturnal GH secretory dynamics [8 PM to 8 AM, Q20 min sampling, analyzed by multiparameter deconvolution and approximate entropy (ApEn) algorithms]. The results were that T administration increased serum total T by 33% (<em>P</em> = 0.004) and E2 by 31% (<em>P</em> = 0.009) and decreased SHBG by 17% (<em>P</em> = 0.002) vs. placebo.</p><p> </p><p>T supplementation increased nocturnal integrated GH concentrations by 60% (<em>P</em> = 0.02) and pulsatile GH secretion by 79% (<em>P</em> = 0.05), primarily due to a twofold increase in GH secretory burst mass (<em>P</em> = 0.02) and a 1.9-fold increase in basal GH secretion rate (<em>P</em> = 0.05) vs. placebo. There were no significant changes in GH burst frequency or orderliness of GH release (ApEn). IGF-I levels increased by 22% (<em>P</em> = 0.02), with no significant change in IGFBP-3 levels after T vs. placebo. </p><p><strong></strong></p><p><strong>We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men.</strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 7478, member: 3"] Even though this study used a low dose of testosterone (100 mg every two weeks of testosterone enanthate injections) in older men with low T, it showed that T supplementation can increase night time growth hormone output. [ATTACH=CONFIG]726[/ATTACH] [B]Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men[/B] - Endocrinology and Metabolism Published 1 September 2007 [B]Vol.[/B] 293 [B]no.[/B] E769-E775 Circulating testosterone (T) and GH/IGF-I are diminished in healthy aging men. Short-term administration of high doses of T augments GH secretion in older men. However, effects of long-term, low-dose T supplementation on GH secretion are unknown. Our objective was to evaluate effects of long-term, low-dose T administration on nocturnal GH secretory dynamics and AM concentrations of IGF-I and IGFBP-3 in healthy older men (65–88 yr, [I]n[/I] = 34) with low-normal T and IGF-I. In a double-masked, placebo-controlled, randomized study we assessed effects of low-dose T supplementation (100 mg im every 2 wk) for 26 wk on nocturnal GH secretory dynamics [8 PM to 8 AM, Q20 min sampling, analyzed by multiparameter deconvolution and approximate entropy (ApEn) algorithms]. The results were that T administration increased serum total T by 33% ([I]P[/I] = 0.004) and E2 by 31% ([I]P[/I] = 0.009) and decreased SHBG by 17% ([I]P[/I] = 0.002) vs. placebo. T supplementation increased nocturnal integrated GH concentrations by 60% ([I]P[/I] = 0.02) and pulsatile GH secretion by 79% ([I]P[/I] = 0.05), primarily due to a twofold increase in GH secretory burst mass ([I]P[/I] = 0.02) and a 1.9-fold increase in basal GH secretion rate ([I]P[/I] = 0.05) vs. placebo. There were no significant changes in GH burst frequency or orderliness of GH release (ApEn). IGF-I levels increased by 22% ([I]P[/I] = 0.02), with no significant change in IGFBP-3 levels after T vs. placebo. [B] We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men.[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Long-term testosterone supplementation augments overnight growth hormone secretion
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