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Long term melatonin supplementation may decrease sperm quality in men
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<blockquote data-quote="JPB" data-source="post: 32516" data-attributes="member: 2659"><p>It seems melatonin's influence on gonadotropins and LH, FSH remains unclear in humans, and in regards to dosage, and age. Some think melatonin levels, which are quite high in childhood, may be an inhibiting factor on sexual maturation. Others point to seasonal variations in hormone levels, with T levels noted to increase in the late summer early fall (subsequent to a period of lower melatonin output from longer daylight hours). With aging melatonin levels typically fall off, as do gonadotropin levels.</p><p></p><p>Unfortunately the full articles usually require paying if you do not have access otherwise.</p><p></p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/19905996" target="_blank"><strong>Melatonin and human reproduction: shedding light on the darkness hormone.</strong></a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/19905996" target="_blank"></a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Srinivasan%20V%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Srinivasan V</a>1, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Spence%20WD%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Spence WD</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Pandi-Perumal%20SR%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Pandi-Perumal SR</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Zakharia%20R%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Zakharia R</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Bhatnagar%20KP%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Bhatnagar KP</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Brzezinski%20A%5BAuthor%5D&cauthor=true&cauthor_uid=19905996" target="_blank">Brzezinski A</a>.</p><p><strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/19905996#" target="_blank">Author information</a></strong></p><p></p><p></p><p></p><p><strong>Abstract</strong></p><p></p><p>Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland and melatonin in human reproduction. Clinical experience related to this issue has yielded inconclusive and sometimes conflicting results. This article reviews the current available evidence concerning the effects of melatonin on human reproductive processes (e.g., puberty, ovulation, pregnancy, and fertility). Possible reasons for the vagueness and elusiveness of the clinical effects are discussed.</p></blockquote><p></p>
[QUOTE="JPB, post: 32516, member: 2659"] It seems melatonin's influence on gonadotropins and LH, FSH remains unclear in humans, and in regards to dosage, and age. Some think melatonin levels, which are quite high in childhood, may be an inhibiting factor on sexual maturation. Others point to seasonal variations in hormone levels, with T levels noted to increase in the late summer early fall (subsequent to a period of lower melatonin output from longer daylight hours). With aging melatonin levels typically fall off, as do gonadotropin levels. Unfortunately the full articles usually require paying if you do not have access otherwise. [URL="http://www.ncbi.nlm.nih.gov/pubmed/19905996"][B]Melatonin and human reproduction: shedding light on the darkness hormone.[/B] [/URL] [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Srinivasan%20V%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Srinivasan V[/URL]1, [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Spence%20WD%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Spence WD[/URL], [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Pandi-Perumal%20SR%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Pandi-Perumal SR[/URL], [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Zakharia%20R%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Zakharia R[/URL], [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Bhatnagar%20KP%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Bhatnagar KP[/URL], [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Brzezinski%20A%5BAuthor%5D&cauthor=true&cauthor_uid=19905996"]Brzezinski A[/URL]. [B][URL="http://www.ncbi.nlm.nih.gov/pubmed/19905996#"]Author information[/URL][/B] [B]Abstract[/B] Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland and melatonin in human reproduction. Clinical experience related to this issue has yielded inconclusive and sometimes conflicting results. This article reviews the current available evidence concerning the effects of melatonin on human reproductive processes (e.g., puberty, ovulation, pregnancy, and fertility). Possible reasons for the vagueness and elusiveness of the clinical effects are discussed. [/QUOTE]
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Long term melatonin supplementation may decrease sperm quality in men
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