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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Lipitor and other Statin Drugs Markedly Decrease Your Testosterone
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<blockquote data-quote="sbstrum_MD" data-source="post: 256981" data-attributes="member: 17682"><p>The paper above is Klinefelter, G.R.; Laskey, J.W.; Amann, R.P. Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: implications for men. Reprod Toxicol 2014, 45, 52-58, doi:10.1016/j.reprotox.2013.12.010</p><p></p><p>There are other peer-reviewed papers involving humans:</p><p>Stanworth, R.D.; Kapoor, D.; Channer, K.S.; Jones, T.H. Statin therapy is associated with lower total but not bioavailable or free testosterone in men with type 2 diabetes. Diabetes Care 2009, 32, 541-546, doi:10.2337/dc08-1183.</p><p></p><p>Corona, G.; Boddi, V.; Balercia, G.; Rastrelli, G.; De Vita, G.; Sforza, A.; Forti, G.; Mannucci, E.; Maggi, M. The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction. J Sex Med 2010, 7, 1547-1556, doi:10.1111/j.1743-6109.2009.01698.x</p><p></p><p>In the Stanworth article, the abstract is shown below:</p><p>OBJECTIVE: There is a high prevalence of hypogonadism in men with type 2 diabetes. This will lead to an increase in assessments of hypogonadism. Statins could potentially decrease testosterone levels by reducing the availability of cholesterol for androgen synthesis. We compared testosterone levels and hypogonadal symptoms with statin use in a cross-sectional study of 355 men with type 2 diabetes. RESEARCH DESIGN AND METHODS: Total testosterone, sex hormone-binding globulin (SHBG), and estradiol were measured by an enzyme-linked immunosorbent assay. Bioavailable testosterone was measured by the modified ammonium sulfate precipitation method. Free testosterone was calculated using Vermeulen's formula. Symptoms of hypogonadism were assessed using the Androgen Deficiency in the Aging Male questionnaire. RESULTS: Statins were associated with lower total testosterone (11.9 vs. 13.4 nmol/l, P = 0.006) and a trend toward lower SHBG (29.4 vs. 35.3 nmol/l, P = 0.034) compared with no treatment. </p><p></p><p>11.9x 28.85= 343 ng/dl </p><p>13.4 x 28.85= 387 ng/dl </p><p></p><p>My comment inserted: This may be significant but doubt it has clinical relevance. </p><p>Bioavailable testosterone, free testosterone, estradiol, and hypogonadal symptoms were not affected. Subanalysis showed that atorvastatin was associated with reduced total testosterone (11.4 vs. 13.4 nmol/l, P = 0.006) and a trend toward reduced SHBG (27.6 vs. 35.3 nmol/l, P = 0.022) compared with no treatment, and there was an apparent dose-response effect with the lowest levels of total testosterone seen in men treated with >or=20 mg atorvastatin (9.6 nmol/l, P = 0.017). Simvastatin use was not associated with significant reductions in testosterone or SHBG levels. CONCLUSIONS: Assessing androgen status using total testosterone in men with type 2 diabetes treated with statins, particularly atorvastatin, may potentially lead to diagnostic error. Levels of bioavailable testosterone or free testosterone are recommended for the assessment of hypogonadism in this group if total testosterone levels are borderline.</p><p></p><p>I showed the calculations above and do not think these results would be noticeable by men on statins. The Stanworth article is attached.</p></blockquote><p></p>
[QUOTE="sbstrum_MD, post: 256981, member: 17682"] The paper above is Klinefelter, G.R.; Laskey, J.W.; Amann, R.P. Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: implications for men. Reprod Toxicol 2014, 45, 52-58, doi:10.1016/j.reprotox.2013.12.010 There are other peer-reviewed papers involving humans: Stanworth, R.D.; Kapoor, D.; Channer, K.S.; Jones, T.H. Statin therapy is associated with lower total but not bioavailable or free testosterone in men with type 2 diabetes. Diabetes Care 2009, 32, 541-546, doi:10.2337/dc08-1183. Corona, G.; Boddi, V.; Balercia, G.; Rastrelli, G.; De Vita, G.; Sforza, A.; Forti, G.; Mannucci, E.; Maggi, M. The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction. J Sex Med 2010, 7, 1547-1556, doi:10.1111/j.1743-6109.2009.01698.x In the Stanworth article, the abstract is shown below: OBJECTIVE: There is a high prevalence of hypogonadism in men with type 2 diabetes. This will lead to an increase in assessments of hypogonadism. Statins could potentially decrease testosterone levels by reducing the availability of cholesterol for androgen synthesis. We compared testosterone levels and hypogonadal symptoms with statin use in a cross-sectional study of 355 men with type 2 diabetes. RESEARCH DESIGN AND METHODS: Total testosterone, sex hormone-binding globulin (SHBG), and estradiol were measured by an enzyme-linked immunosorbent assay. Bioavailable testosterone was measured by the modified ammonium sulfate precipitation method. Free testosterone was calculated using Vermeulen's formula. Symptoms of hypogonadism were assessed using the Androgen Deficiency in the Aging Male questionnaire. RESULTS: Statins were associated with lower total testosterone (11.9 vs. 13.4 nmol/l, P = 0.006) and a trend toward lower SHBG (29.4 vs. 35.3 nmol/l, P = 0.034) compared with no treatment. 11.9x 28.85= 343 ng/dl 13.4 x 28.85= 387 ng/dl My comment inserted: This may be significant but doubt it has clinical relevance. Bioavailable testosterone, free testosterone, estradiol, and hypogonadal symptoms were not affected. Subanalysis showed that atorvastatin was associated with reduced total testosterone (11.4 vs. 13.4 nmol/l, P = 0.006) and a trend toward reduced SHBG (27.6 vs. 35.3 nmol/l, P = 0.022) compared with no treatment, and there was an apparent dose-response effect with the lowest levels of total testosterone seen in men treated with >or=20 mg atorvastatin (9.6 nmol/l, P = 0.017). Simvastatin use was not associated with significant reductions in testosterone or SHBG levels. CONCLUSIONS: Assessing androgen status using total testosterone in men with type 2 diabetes treated with statins, particularly atorvastatin, may potentially lead to diagnostic error. Levels of bioavailable testosterone or free testosterone are recommended for the assessment of hypogonadism in this group if total testosterone levels are borderline. I showed the calculations above and do not think these results would be noticeable by men on statins. The Stanworth article is attached. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Lipitor and other Statin Drugs Markedly Decrease Your Testosterone
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