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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Leydig stem cells and future therapies for hypogonadism
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<blockquote data-quote="madman" data-source="post: 190310" data-attributes="member: 13851"><p><strong>KEY POINTS </strong></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>●</strong></span><span style="color: rgb(184, 49, 47)"><strong> In-vitro studies have shown that both induction of stem cells into adult Leydig cells and direct harvesting of LSCs for grafting purposes are viable methods of increasing testosterone levels. Similarly, in-vivo rodent studies show that LSC harvesting and later grafting significantly increase testosterone levels with minimal effects on hypothalamic-pituitary-gonadal axis signaling. </strong></span></p><p><strong></strong></p><p><strong><span style="color: rgb(0, 0, 0)">●</span><span style="color: rgb(184, 49, 47)"> Both intranasal (Natesto) testosterone and oral testosterone undecanoate have been shown to treat symptomatic hypogonadism in men, with minimal side effects. </span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><strong><span style="color: rgb(0, 0, 0)">●</span><span style="color: rgb(184, 49, 47)"> Enclomiphene citrate has not shown any difference in side effect profile when compared with clomiphene citrate; however, it has been shown to preserve or improve spermatogenesis when compared with testosterone gels. </span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><span style="color: rgb(0, 0, 0)"><strong>●</strong></span><span style="color: rgb(184, 49, 47)"><strong> Selective androgen receptor modulators are currently not being used to treat symptomatic male hypogonadism; however, their similarity to selective estrogen modulators could make them a potential future treatment for low testosterone. </strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 190310, member: 13851"] [B]KEY POINTS [/B] [COLOR=rgb(0, 0, 0)][B]●[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] In-vitro studies have shown that both induction of stem cells into adult Leydig cells and direct harvesting of LSCs for grafting purposes are viable methods of increasing testosterone levels. Similarly, in-vivo rodent studies show that LSC harvesting and later grafting significantly increase testosterone levels with minimal effects on hypothalamic-pituitary-gonadal axis signaling. [/B][/COLOR] [B][COLOR=rgb(184, 49, 47)][/COLOR] [COLOR=rgb(0, 0, 0)]●[/COLOR][COLOR=rgb(184, 49, 47)] Both intranasal (Natesto) testosterone and oral testosterone undecanoate have been shown to treat symptomatic hypogonadism in men, with minimal side effects. [/COLOR] [COLOR=rgb(0, 0, 0)]●[/COLOR][COLOR=rgb(184, 49, 47)] Enclomiphene citrate has not shown any difference in side effect profile when compared with clomiphene citrate; however, it has been shown to preserve or improve spermatogenesis when compared with testosterone gels. [/COLOR][/B] [COLOR=rgb(0, 0, 0)][B]●[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] Selective androgen receptor modulators are currently not being used to treat symptomatic male hypogonadism; however, their similarity to selective estrogen modulators could make them a potential future treatment for low testosterone. [/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Leydig stem cells and future therapies for hypogonadism
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