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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Levothyroxine kicking in in the evenings
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<blockquote data-quote="trtthings" data-source="post: 192942" data-attributes="member: 41094"><p>Been thinking this over back and forth. </p><p></p><p>I think the following theory makes sense: </p><p></p><p>[USER=38109]@Cataceous[/USER] [USER=843]@Vince[/USER] </p><p></p><p>As we've seen in euthyroid subjects, the levels of T4 are relatively stable whereas TSH and T3 have a diurnal rhythm. FT3 following TSH by maybe 90 minutes, as if TSH is driving the T4 -> T3 conversion with little effect on T4. </p><p></p><p>There's a negative feedback with TSH, much like testosterone/estradiol and LH. So you supplement with Levothyroxine, it reaches the peak in the serum within 3 hours (although T4 levels are relatively stable). It's not unreasonable to think that this would cause some suppression and thus suppress the TSH mediated T4 -> T3 conversion for the next few (many) hours. </p><p></p><p>I feel the effects in the evening, so it's not unreasonable to think that by then I might have been getting some TSH and then T4 -> T3 conversion. </p><p></p><p>I've also read many stories by thyroid patients who were tired all day until they switched to an evening intake of T4. It seems counter-intuitive at first with the relatively stable levels of T4 (given the 1-week half life). But I'm still guessing it matters, at least for some.</p><p></p><p>I tried this myself now.. all the days I took 50mcg in the morning I started feeling it after around 10 hours. I tried one day with 75mcg in the morning and the onset was slightly later. Then I tried 75mcg in the evening and I started feeling the effect/being more awake/feeling better around noon the next day. </p><p></p><p>Doesn't really matter if I'm right or wrong as long as the end result is that I'm feeling better. </p><p></p><p>However I think this probably partially explains why some thyroid associations recommend/say patients often don't feel good until they have T4 levels high in the range or just outside of the normal range. I think the TSH suppression, firstly.. it suppresses the T3 secreted from the thyroid. If I recall this is thought to be about 20% of the total T3. And secondly it may be suppressing this T4 -> T3 conversion by suppressing TSH.</p></blockquote><p></p>
[QUOTE="trtthings, post: 192942, member: 41094"] Been thinking this over back and forth. I think the following theory makes sense: [USER=38109]@Cataceous[/USER] [USER=843]@Vince[/USER] As we've seen in euthyroid subjects, the levels of T4 are relatively stable whereas TSH and T3 have a diurnal rhythm. FT3 following TSH by maybe 90 minutes, as if TSH is driving the T4 -> T3 conversion with little effect on T4. There's a negative feedback with TSH, much like testosterone/estradiol and LH. So you supplement with Levothyroxine, it reaches the peak in the serum within 3 hours (although T4 levels are relatively stable). It's not unreasonable to think that this would cause some suppression and thus suppress the TSH mediated T4 -> T3 conversion for the next few (many) hours. I feel the effects in the evening, so it's not unreasonable to think that by then I might have been getting some TSH and then T4 -> T3 conversion. I've also read many stories by thyroid patients who were tired all day until they switched to an evening intake of T4. It seems counter-intuitive at first with the relatively stable levels of T4 (given the 1-week half life). But I'm still guessing it matters, at least for some. I tried this myself now.. all the days I took 50mcg in the morning I started feeling it after around 10 hours. I tried one day with 75mcg in the morning and the onset was slightly later. Then I tried 75mcg in the evening and I started feeling the effect/being more awake/feeling better around noon the next day. Doesn't really matter if I'm right or wrong as long as the end result is that I'm feeling better. However I think this probably partially explains why some thyroid associations recommend/say patients often don't feel good until they have T4 levels high in the range or just outside of the normal range. I think the TSH suppression, firstly.. it suppresses the T3 secreted from the thyroid. If I recall this is thought to be about 20% of the total T3. And secondly it may be suppressing this T4 -> T3 conversion by suppressing TSH. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Levothyroxine kicking in in the evenings
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